{"id":"W4294794606","doi":"10.1002/1878-0261.13312","title":"Targeting senescence as an anticancer therapy","year":2022,"lang":"en","type":"review","venue":"Molecular Oncology","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council Canada; Cancer Research UK","keywords":"Senescence; Cancer; Cancer research; Cellular senescence; Cancer cell; Metastasis; Biology; Phenotype; Medicine; Cell biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005484866,0.0006107424,0.002544167,0.0003164334,0.0001947566,0.00002639719,0.0005116948,0.0005488603,0.003055266],"category_scores_gemma":[0.000242584,0.0005224448,0.0005609558,0.000658694,0.0002095072,0.00005960129,0.0001748898,0.001167264,0.000194934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005640445,"about_ca_system_score_gemma":0.00233793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001216765,"about_ca_topic_score_gemma":0.000005816972,"domain_scores_codex":[0.9960707,0.000868741,0.0007742161,0.001034845,0.0005470551,0.0007044739],"domain_scores_gemma":[0.9980251,0.0002184788,0.0004172464,0.0009000205,0.00008587844,0.0003533081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006931782,0.000369733,0.00001950038,0.00192627,0.0002136688,0.004440905,0.0001284859,8.071052e-7,0.0005720051,0.0001942545,0.0005064639,0.9915586],"study_design_scores_gemma":[0.0006409044,0.001441673,0.000006311876,0.0007862362,0.0004869051,0.001252516,0.00008194498,0.00001106584,0.00006886341,0.00003402922,0.9946901,0.0004995113],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003636187,0.9942331,0.0001565498,0.0001753121,0.0007852668,0.001313704,0.0000173228,0.0001671448,0.002788011],"genre_scores_gemma":[0.0001389721,0.9944137,0.001022317,0.002665598,0.00038754,0.0003104803,0.0004355663,0.0001625785,0.0004632194],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9941836,"threshold_uncertainty_score":0.9997227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07691729321967544,"score_gpt":0.4171504149027289,"score_spread":0.3402331216830535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}