{"id":"W4294805304","doi":"10.1101/2022.08.31.506095","title":"More than a ligand: PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I interferon pathway","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal; Ottawa Hospital; Institute of Infection and Immunity; University of Ottawa","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Canadian Allergy, Asthma and Immunology Foundation; Universities Space Research Association; Natural Sciences and Engineering Research Council of Canada; Ottawa Hospital Research Institute; Terry Fox Foundation; Terry Fox Research Institute; University of Ottawa","keywords":"Oncolytic virus; Interferon; Virotherapy; Immune system; Cancer research; Cancer cell; Biology; Cancer; PD-L1; Immunology; Immunotherapy; Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003032858,0.0002593933,0.0003547582,0.0001521628,0.0002921693,0.0007596529,0.0002002312,0.0005752183,0.01108329],"category_scores_gemma":[0.000389623,0.00009683539,0.0002380335,0.00007920033,0.0001631051,0.0003831539,0.0001993996,0.0006451027,0.002097405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005380363,"about_ca_system_score_gemma":0.0004533762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000224036,"about_ca_topic_score_gemma":0.0004388079,"domain_scores_codex":[0.9997874,0.00003627225,0.00002886475,0.00004216579,0.00008121866,0.0000242165],"domain_scores_gemma":[0.9997841,0.00005833562,0.00005228892,0.00001237814,0.00004916574,0.00004365775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001393462,0.0002406178,0.00111375,0.0008375206,0.00005569465,0.0007089707,0.00009866113,0.0003613711,0.8868252,0.006053349,0.06296001,0.03935146],"study_design_scores_gemma":[0.0002365934,0.001321139,0.003682778,0.00009249205,0.00009296684,0.001764896,0.0001742068,0.002340904,0.7464578,0.001533388,0.2422625,0.0000403648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7124992,0.03482849,0.03141123,0.08109114,0.04225393,0.0005810342,0.004832357,0.002898104,0.08960449],"genre_scores_gemma":[0.8999473,0.004518358,0.005134145,0.008496393,0.003054569,0.0001520528,0.000722829,0.0002253952,0.07774892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01108329,"threshold_uncertainty_score":0.03707725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02018644440405029,"score_gpt":0.265048044141434,"score_spread":0.2448615997373837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}