{"id":"W4294832783","doi":"10.1101/2022.09.05.503899","title":"The cytidine deaminase APOBEC3G drives cancer mutagenesis and clonal evolution in bladder cancer","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Weill Cornell Medical College","keywords":"Cytidine deaminase; Somatic hypermutation; Mutagenesis; APOBEC3G; Biology; APOBEC; Cancer; Genetics; Insertional mutagenesis; Somatic evolution in cancer; Cancer research; Genome instability; Mutation; Cancer cell; Gene; Computational biology; Genome; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001493725,0.0001401565,0.0001397966,0.0003190871,0.0001722037,0.0002928011,0.0001072547,0.0002617682,0.001177831],"category_scores_gemma":[0.0001475194,0.0001217754,0.0001447062,0.000236705,0.0001786968,0.0001032407,0.0002421737,0.0003669542,0.0003228936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003904756,"about_ca_system_score_gemma":0.0001964168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001568733,"about_ca_topic_score_gemma":0.001878636,"domain_scores_codex":[0.9998971,0.00001376958,0.000004543439,0.00002574559,0.00004012169,0.0000187002],"domain_scores_gemma":[0.9999157,0.0000175218,0.00002294594,0.00001494688,0.00001136745,0.00001752066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006334644,0.00001432496,0.001819863,0.00002169874,0.0000061049,0.0000597806,0.00001514727,0.0003454664,0.9943288,0.0003397229,0.0002356395,0.002750169],"study_design_scores_gemma":[0.000019172,0.0001270944,0.03054004,0.000009029581,0.00001752407,0.0007529148,0.0000446667,0.009487236,0.9516048,0.0009029012,0.006485835,0.000008829063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876828,0.001041373,0.007886058,0.0001887831,0.00002219078,0.00001570501,0.0007861159,0.0002609536,0.002116015],"genre_scores_gemma":[0.9927633,0.0003175855,0.003376188,0.00004659008,0.000007094738,0.000008755786,0.0005975586,0.0000391129,0.002843714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001568733,"threshold_uncertainty_score":0.003940165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007596363964380921,"score_gpt":0.2300856030998938,"score_spread":0.2224892391355129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}