{"id":"W4294878008","doi":"10.1016/j.biosystems.2022.104774","title":"The reversibility of cellular determination: An evolutive pattern of epigenetic plasticity","year":2022,"lang":"en","type":"article","venue":"Biosystems","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland","funders":"","keywords":"Transdifferentiation; Epigenetics; Reprogramming; Biology; Epigenesis; Plasticity; Neuroscience; Feature (linguistics); Evolutionary biology; Computer science; Cell; Genetics; DNA methylation; Gene expression; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005503509,0.0002050564,0.0002954454,0.000565071,0.0003564295,0.001080182,0.0008358852,0.0004749561,0.002732614],"category_scores_gemma":[0.00178316,0.0002180875,0.0002227931,0.0003149576,0.001801439,0.00124527,0.0009261279,0.0009579909,0.0004292054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000490652,"about_ca_system_score_gemma":0.0003329526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002239273,"about_ca_topic_score_gemma":0.0003815286,"domain_scores_codex":[0.9995826,0.0000635629,0.00002293777,0.0001458154,0.0001372257,0.00004791605],"domain_scores_gemma":[0.998806,0.0003721889,0.000138477,0.0004513733,0.0001430771,0.00008890563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0001681615,0.00003477099,0.006426698,0.0001008513,0.00004673111,0.0002749999,0.0004625621,0.001858484,0.8200042,0.1036681,0.0005024686,0.06645207],"study_design_scores_gemma":[0.00008427676,0.0009331769,0.1547644,0.0001112096,0.0001197237,0.003287522,0.0009915562,0.01407706,0.6212865,0.1591267,0.04503409,0.0001837837],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8708122,0.004271708,0.07701419,0.001888501,0.0002217385,0.00004449149,0.0003792552,0.0005797991,0.04478806],"genre_scores_gemma":[0.9903764,0.0008359157,0.004074101,0.0002006397,0.00005034658,0.00001692028,0.0001065412,0.00009029414,0.0042488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002732614,"threshold_uncertainty_score":0.009141445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01465785160768158,"score_gpt":0.2548279566507088,"score_spread":0.2401701050430272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}