{"id":"W4294904260","doi":"10.1038/s41588-022-01165-1","title":"Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention","year":2022,"lang":"en","type":"review","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":236,"is_retracted":false,"has_abstract":true,"ca_institutions":"Impact; Université Laval; McMaster University","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; Helmholtz Zentrum München; Statens Serum Institut; Feinberg School of Medicine; National Institutes of Health; Novo Nordisk Foundation Center for Basic Metabolic Research; Medical Research Council; Uppsala Universitet; Tartu Ülikool; Technische Universität München; British Heart Foundation; China Scholarship Council; Vetenskapsrådet; National Cancer Institute; University College London; Université de Lausanne; Karolinska Institutet; Seoul National University; Northwestern University; Genome Institute of Singapore; National Research Foundation of Korea; Ministry of Science, ICT and Future Planning; Novo Nordisk; Universität Greifswald; Hjärt-Lungfonden; Agency for Science, Technology and Research; University of Surrey; National Institute for Health and Care Research; National Research Foundation; University of Bristol; Wellcome Trust; Cancer Research UK; Faculty of Health and Medical Sciences, University of Western Australia; University of Leicester; Kjell och Märta Beijers Stiftelse; University of Miami; Eunice Kennedy Shriver National Institute of Child Health and Human Development; GlaxoSmithKline; Universidade Federal de Pelotas; KU Leuven; Duke-NUS Medical School; QIMR Berghofer Medical Research Institute; School of Public Health, University of Michigan; National Institute of Environmental Health Sciences; School of Medicine, Boston University; Steno Diabetes Center Copenhagen; McMaster University; Imperial College London; Det Sundhedsvidenskabelige Fakultet, Københavns Universitet; University of North Carolina at Chapel Hill; Science for Life Laboratory; National Science Foundation; Oak Foundation; Novo Nordisk Fonden; American Heart Association; University of California, Los Angeles; University of Washington; Brigham and Women's Hospital; Heart and Stroke Foundation of Canada; National Health and Medical Research Council; Oulun Yliopisto; NIHR Leicester Biomedical Research Centre; U.S. Department of Veterans Affairs","keywords":"Biology; Genome-wide association study; Association (psychology); Disease; Genetics; Sedentary behavior; Genetic association; Computational biology; Physical activity; Genome; Evolutionary biology; Gene; Single-nucleotide polymorphism; Genotype; Obesity; Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002746895,0.0002826335,0.000745595,0.0001503251,0.00009433561,0.00001632437,0.0001456155,0.0005963679,0.000003749449],"category_scores_gemma":[0.0003532475,0.0002675228,0.0002118321,0.0001678023,0.00003697585,0.000004705299,0.0002881855,0.0004701183,2.358227e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001442535,"about_ca_system_score_gemma":0.0002167752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000231169,"about_ca_topic_score_gemma":0.0001763864,"domain_scores_codex":[0.9982387,0.0004905779,0.0003385317,0.0005276085,0.0002030757,0.0002014695],"domain_scores_gemma":[0.9988841,0.0001680735,0.0005580398,0.0002563813,0.00004699464,0.00008641691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.00006704282,0.0009786435,0.05984943,0.005009803,0.001030965,0.00001598419,0.0003799665,0.0002362635,0.007958404,0.00002232077,0.00006224798,0.9243889],"study_design_scores_gemma":[0.00147245,0.001317987,0.6144772,0.0009767005,0.007172138,0.000009895878,0.0002807129,0.0004398995,0.0008669739,0.004403727,0.3667857,0.00179665],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.4086362,0.5906885,0.0001269585,0.00001568661,0.0000504863,0.000440811,0.00003248073,0.00000332295,0.000005555196],"genre_scores_gemma":[0.258826,0.7397724,0.0006004921,0.00002911743,0.00006188526,0.0001271187,0.0005105084,0.00002591569,0.00004661067],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9225923,"threshold_uncertainty_score":0.9999777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04293197152893032,"score_gpt":0.3769140334785058,"score_spread":0.3339820619495755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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