{"id":"W4294904260","doi":"10.1038/s41588-022-01165-1","title":"Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention","year":2022,"lang":"en","type":"review","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":236,"is_retracted":false,"has_abstract":true,"ca_institutions":"Impact; Université Laval; McMaster University","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; Helmholtz Zentrum München; Statens Serum Institut; Feinberg School of Medicine; National Institutes of Health; Novo Nordisk Foundation Center for Basic Metabolic Research; Medical Research Council; Uppsala Universitet; Tartu Ülikool; Technische Universität München; British Heart Foundation; China Scholarship Council; Vetenskapsrådet; National Cancer Institute; University College London; Université de Lausanne; Karolinska Institutet; Seoul National University; Northwestern University; Genome Institute of Singapore; National Research Foundation of Korea; Ministry of Science, ICT and Future Planning; Novo Nordisk; Universität Greifswald; Hjärt-Lungfonden; Agency for Science, Technology and Research; University of Surrey; National Institute for Health and Care Research; National Research Foundation; University of Bristol; Wellcome Trust; Cancer Research UK; Faculty of Health and Medical Sciences, University of Western Australia; University of Leicester; Kjell och Märta Beijers Stiftelse; University of Miami; Eunice Kennedy Shriver National Institute of Child Health and Human Development; GlaxoSmithKline; Universidade Federal de Pelotas; KU Leuven; Duke-NUS Medical School; QIMR Berghofer Medical Research Institute; School of Public Health, University of Michigan; National Institute of Environmental Health Sciences; School of Medicine, Boston University; Steno Diabetes Center Copenhagen; McMaster University; Imperial College London; Det Sundhedsvidenskabelige Fakultet, Københavns Universitet; University of North Carolina at Chapel Hill; Science for Life Laboratory; National Science Foundation; Oak Foundation; Novo Nordisk Fonden; American Heart Association; University of California, Los Angeles; University of Washington; Brigham and Women's Hospital; Heart and Stroke Foundation of Canada; National Health and Medical Research Council; Oulun Yliopisto; NIHR Leicester Biomedical Research Centre; U.S. Department of Veterans Affairs","keywords":"Biology; Genome-wide association study; Association (psychology); Disease; Genetics; Sedentary behavior; Genetic association; Computational biology; Physical activity; Genome; Evolutionary biology; Gene; Single-nucleotide polymorphism; Genotype; Obesity; Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002164042,0.001297904,0.003091815,0.003006063,0.0001998545,0.00113332,0.001200715,0.001644275,0.00382074],"category_scores_gemma":[0.002943561,0.000407729,0.001193474,0.00294649,0.0006796038,0.0009093952,0.0007327837,0.002378981,0.001753537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009193062,"about_ca_system_score_gemma":0.001559485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001841005,"about_ca_topic_score_gemma":0.002964229,"domain_scores_codex":[0.9994779,0.0001594466,0.00007118178,0.000118667,0.0001336574,0.00003918403],"domain_scores_gemma":[0.9975463,0.001698854,0.0001981291,0.00005420027,0.0003902676,0.0001122984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0002163991,0.00006380677,0.0008411574,0.02240648,0.000940139,0.0001513849,0.00003055363,0.0004217954,0.0005183046,0.003392343,0.02419174,0.9468259],"study_design_scores_gemma":[0.0001530427,0.0002797285,0.009230884,0.02224557,0.00221489,0.001742682,0.0001011504,0.0003494153,0.0005664424,0.008269693,0.9547676,0.00007887382],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005155758,0.9990231,0.0001260729,0.0003628387,0.0001453613,0.000002613236,0.00002578807,0.00000552924,0.0002571211],"genre_scores_gemma":[0.0005048879,0.998781,0.000155899,0.0001997772,0.0001379665,0.000005613325,0.0000350595,0.000001777101,0.0001779559],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00382074,"threshold_uncertainty_score":0.01278168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04293197152893032,"score_gpt":0.3769140334785058,"score_spread":0.3339820619495755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}