{"id":"W4294904531","doi":"10.1038/s41588-022-01168-y","title":"Genetic determinants of chromatin reveal prostate cancer risk mediated by context-dependent gene regulation","year":2022,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; National Human Genome Research Institute; National Institute of Mental Health; Pharmaceutical Research and Manufacturers of America Foundation","keywords":"Biology; Chromatin; Context (archaeology); Prostate cancer; Genetics; Gene; Cancer; Computational biology; Evolutionary biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003776948,0.0002260076,0.0002576728,0.0000700388,0.0001940943,0.00001532487,0.0002956091,0.0003081502,0.00008150018],"category_scores_gemma":[0.0001011181,0.0002389872,0.0001111393,0.0001872732,0.00006697952,0.000002819101,0.0002341778,0.0003403392,0.000002085837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005369343,"about_ca_system_score_gemma":0.0001509611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001108133,"about_ca_topic_score_gemma":0.0001442776,"domain_scores_codex":[0.9979392,0.0002356536,0.0005199375,0.0004938662,0.0005150196,0.0002963609],"domain_scores_gemma":[0.9987056,0.00002482241,0.000467791,0.0005092783,0.0001957666,0.00009673386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001080679,0.00008517227,0.1223906,0.0000287665,0.0000773679,0.000002357621,0.0001235263,0.004437702,0.836917,6.769945e-7,0.001388623,0.03444012],"study_design_scores_gemma":[0.000925019,0.0005130072,0.1013182,0.000007860689,0.00008274829,0.000005285607,0.00005199237,0.001171598,0.8750092,0.0001264967,0.02049364,0.000294981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9328783,0.06482162,0.0002145303,0.00003574757,0.0004014833,0.0004629481,0.00112885,0.00001215629,0.00004439849],"genre_scores_gemma":[0.992716,0.004774912,0.001120167,0.0001108679,0.0001709303,0.0001052094,0.000456541,0.00005289726,0.0004924882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06004671,"threshold_uncertainty_score":0.9745613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005024607780222015,"score_gpt":0.254928239060718,"score_spread":0.249903631280496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}