{"id":"W4294916329","doi":"10.1002/hep.32777","title":"Serum biomarkers correlated with liver stiffness assessed in a multicenter study of pediatric cholestatic liver disease","year":2022,"lang":"en","type":"article","venue":"Hepatology","topic":"Pediatric Hepatobiliary Diseases and Treatments","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Center for Research Resources; Agency for Healthcare Research and Quality; National Center for Advancing Translational Sciences; Audentes Therapeutics; National Institute of Diabetes and Digestive and Kidney Diseases; Gilead Sciences","keywords":"CTGF; Biomarker; Medicine; Internal medicine; Gastroenterology; Liver disease; Periostin; TIMP1; Fibrosis; Cholestasis; Biliary atresia; Pathology; Growth factor; Extracellular matrix; Biology; Liver transplantation; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001106192,0.0004620448,0.0004601346,0.00074183,0.0003389594,0.0005497351,0.0003251948,0.0004722384,0.0006920238],"category_scores_gemma":[0.004287263,0.0002568266,0.0003859341,0.0008729305,0.0002937616,0.0003822185,0.0004705947,0.0005886938,0.000120989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003858752,"about_ca_system_score_gemma":0.0004149264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003162279,"about_ca_topic_score_gemma":0.003035501,"domain_scores_codex":[0.9990957,0.0003415139,0.0001140581,0.0001884516,0.0001674176,0.00009276959],"domain_scores_gemma":[0.9960426,0.0004572955,0.002485319,0.0001561115,0.0003907586,0.0004679909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002563014,0.000006899892,0.9995975,0.000002914819,0.00001934514,0.00003186652,0.00002311658,0.00001587725,0.00008946935,0.000003588373,0.00001842581,0.0001654233],"study_design_scores_gemma":[0.000004011587,0.00007513269,0.9993595,0.000003292686,0.00001442277,0.0002919747,0.00005209419,0.0000937488,0.00005390502,0.000005278489,0.00004524127,0.000001394929],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999397,0.0001828188,0.00005482001,0.00003570548,0.000003269719,0.000005055371,0.0002111381,0.000003133179,0.0001071349],"genre_scores_gemma":[0.9994884,0.00006191887,0.0001313913,0.00001372022,0.000006213641,0.00001127909,0.0002527014,0.000001510466,0.00003292092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003162279,"threshold_uncertainty_score":0.006287694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01780484003648724,"score_gpt":0.2649553381250414,"score_spread":0.2471504980885542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}