{"id":"W4294916329","doi":"10.1002/hep.32777","title":"Serum biomarkers correlated with liver stiffness assessed in a multicenter study of pediatric cholestatic liver disease","year":2022,"lang":"en","type":"article","venue":"Hepatology","topic":"Pediatric Hepatobiliary Diseases and Treatments","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Center for Research Resources; Agency for Healthcare Research and Quality; National Center for Advancing Translational Sciences; Audentes Therapeutics; National Institute of Diabetes and Digestive and Kidney Diseases; Gilead Sciences","keywords":"CTGF; Biomarker; Medicine; Internal medicine; Gastroenterology; Liver disease; Periostin; TIMP1; Fibrosis; Cholestasis; Biliary atresia; Pathology; Growth factor; Extracellular matrix; Biology; Liver transplantation; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001097326,0.000222236,0.0004843876,0.0004193911,0.00008790663,0.000005024004,0.0001222496,0.00004599018,0.0005054421],"category_scores_gemma":[0.0000585746,0.0001870296,0.00007679251,0.0008070194,0.00005623319,0.00007081185,0.000135003,0.0002262225,0.00001719893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001736744,"about_ca_system_score_gemma":0.0004104814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001270193,"about_ca_topic_score_gemma":0.000346718,"domain_scores_codex":[0.9980624,0.0003477948,0.0004052509,0.0004609699,0.0003673315,0.0003562114],"domain_scores_gemma":[0.9989213,0.0001602674,0.0001797007,0.0003852208,0.0000768789,0.0002765884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003672606,0.01123313,0.9701682,0.0002058012,0.0002545544,0.01306895,0.0005936479,0.00004940258,0.000002164172,0.000003418842,0.0001499686,0.0005981837],"study_design_scores_gemma":[0.01366324,0.001130539,0.9683175,0.0000117461,0.001404516,0.00005032222,0.0007739487,0.0144455,8.685262e-7,0.000003163875,0.00003431892,0.0001643502],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972818,0.0008345213,0.000005643508,0.00006513783,0.0001310697,0.001477607,0.0001163132,0.00004488061,0.00004306238],"genre_scores_gemma":[0.9991468,0.0001633075,0.00003417888,0.0001382369,0.00002222592,0.0003093053,0.00008850169,0.00003289478,0.00006459963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01439609,"threshold_uncertainty_score":0.7626844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01780484003648724,"score_gpt":0.2649553381250414,"score_spread":0.2471504980885542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}