{"id":"W4294917672","doi":"10.1128/jvi.00776-22","title":"Avian Influenza NS1 Proteins Inhibit Human, but Not Duck, RIG-I Ubiquitination and Interferon Signaling","year":2022,"lang":"en","type":"article","venue":"Journal of Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Government of Canada; American Lebanese Syrian Associated Charities","keywords":"Biology; Influenza A virus subtype H5N1; Waterfowl; Virology; Population; Interferon; Influenza A virus; Ubiquitin; RIG-I; Virus; Immunology; Ecology; Genetics; Innate immune system; Gene; Immune system; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009176549,0.0001660198,0.0003918847,0.0004030013,0.0004082597,0.00001941951,0.0002625736,0.0001676321,0.001765842],"category_scores_gemma":[0.0001383924,0.0001510755,0.0001177736,0.00008024429,0.0002215265,0.0001485205,0.0002617395,0.001018667,0.00003826848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001040495,"about_ca_system_score_gemma":0.00007727616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004498743,"about_ca_topic_score_gemma":0.00001100197,"domain_scores_codex":[0.9979188,0.0008466204,0.0006876538,0.0001778631,0.0000672805,0.0003018261],"domain_scores_gemma":[0.9990053,0.0001472842,0.0005549688,0.0001409063,0.00012326,0.00002827517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00283845,0.000155073,0.0004483362,0.00001254099,0.0001441368,0.00004403428,0.001236767,0.00001653004,0.9923146,0.0006455767,0.0006303609,0.001513625],"study_design_scores_gemma":[0.003695088,0.009382598,0.005465155,0.00004567191,0.00008613666,0.003794372,0.001719568,0.000005977066,0.9166673,0.0004278142,0.05846788,0.000242425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960587,0.001793219,0.0001194207,0.0009563402,0.0006366021,0.0001636536,0.00001480457,0.00001733848,0.0002398957],"genre_scores_gemma":[0.996993,0.00002213501,0.00004576039,0.001331883,0.00007224516,0.00001530797,0.00000924394,0.00001879183,0.001491632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07564726,"threshold_uncertainty_score":0.9991467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0199486526829586,"score_gpt":0.2705132900671914,"score_spread":0.2505646373842328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}