{"id":"W4294917672","doi":"10.1128/jvi.00776-22","title":"Avian Influenza NS1 Proteins Inhibit Human, but Not Duck, RIG-I Ubiquitination and Interferon Signaling","year":2022,"lang":"en","type":"article","venue":"Journal of Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Government of Canada; American Lebanese Syrian Associated Charities","keywords":"Biology; Influenza A virus subtype H5N1; Waterfowl; Virology; Population; Interferon; Influenza A virus; Ubiquitin; RIG-I; Virus; Immunology; Ecology; Genetics; Innate immune system; Gene; Immune system; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001451591,0.0002835109,0.0001829623,0.00007107672,0.0001374014,0.0002114446,0.0001213793,0.0001856591,0.001086923],"category_scores_gemma":[0.00009069985,0.00007644534,0.0002021516,0.00004453792,0.0001739089,0.0001074589,0.0001024999,0.000282983,0.0003374326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002614579,"about_ca_system_score_gemma":0.0002043037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007845591,"about_ca_topic_score_gemma":0.001736393,"domain_scores_codex":[0.9998636,0.00003299188,0.00001347214,0.00002087071,0.00002895673,0.0000400862],"domain_scores_gemma":[0.9999397,0.00001311955,0.00001773576,0.000009007707,0.000008050651,0.00001228073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001534365,0.00003545259,0.0004634381,0.00005164745,0.000009305131,0.00001558493,0.00000952824,0.00008841927,0.9976075,0.00007600572,0.00007203197,0.001417672],"study_design_scores_gemma":[0.00002178597,0.0004742942,0.01014118,0.000009370101,0.00001339601,0.0002487786,0.00004211231,0.0008896385,0.9857903,0.00004390545,0.00232161,0.000003702059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935002,0.002490717,0.0009079892,0.00009287767,0.00002867306,0.00001567421,0.0001862003,0.00002173287,0.002755992],"genre_scores_gemma":[0.9970776,0.0006100283,0.0006645807,0.00006548816,0.000004454044,0.00001072861,0.0002144344,0.000004808343,0.001347951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001086923,"threshold_uncertainty_score":0.003636122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0199486526829586,"score_gpt":0.2705132900671914,"score_spread":0.2505646373842328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}