{"id":"W4294967876","doi":"10.1016/s2213-8587(22)00221-2","title":"Paediatric patients with heterozygous familial hypercholesterolaemia treated with evolocumab for 80 weeks (HAUSER-OLE): a single-arm, multicentre, open-label extension of HAUSER-RCT","year":2022,"lang":"en","type":"article","venue":"The Lancet Diabetes & Endocrinology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Chicoutimi; Centre hospitalier universitaire de Québec","funders":"HLS Therapeutics; Amgen; ZonMw; Sanofi; Kowa Company; Novo Nordisk; Medicines Company; F. Hoffmann-La Roche; Abbott Laboratories; Regeneron Pharmaceuticals; Novartis; Pfizer","keywords":"Medicine; Evolocumab; Placebo; Adverse effect; Randomized controlled trial; Clinical endpoint; Internal medicine; Population; Cholesterol; Lipoprotein; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002821115,0.001445887,0.003620999,0.0002894193,0.0004120712,0.001007379,0.0006173683,0.001710919,0.005082486],"category_scores_gemma":[0.002907195,0.0005460056,0.004655954,0.0003298256,0.0009616833,0.001417661,0.0008700888,0.002489215,0.0005527099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006633435,"about_ca_system_score_gemma":0.001143572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001225773,"about_ca_topic_score_gemma":0.002749239,"domain_scores_codex":[0.998533,0.0007709197,0.0001435399,0.0002477736,0.0001083223,0.0001964465],"domain_scores_gemma":[0.9988096,0.0003671715,0.0003674924,0.0001616963,0.00007514644,0.0002189876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9374092,0.003723539,0.004472886,0.004393514,0.007338775,0.0002936157,0.0002868255,0.0003501392,0.003014593,0.0004067541,0.001131005,0.0371791],"study_design_scores_gemma":[0.9268864,0.05367982,0.01136694,0.0005085942,0.00464767,0.0002047268,0.000149604,0.0002033849,0.0004186916,0.000318751,0.001565588,0.00004975266],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808697,0.01230806,0.0007349771,0.0006867611,0.0005715076,0.002129935,0.0009543572,0.00006566544,0.001678965],"genre_scores_gemma":[0.98566,0.004742766,0.003016911,0.001000285,0.0003332002,0.002962147,0.0008518464,0.00002238453,0.001410522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005082486,"threshold_uncertainty_score":0.01700264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03278071262394313,"score_gpt":0.2689145794673222,"score_spread":0.236133866843379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}