{"id":"W4294989680","doi":"10.3390/biomedicines10092168","title":"Rational Generation of Monoclonal Antibodies Selective for Pathogenic Forms of Alpha-Synuclein","year":2022,"lang":"en","type":"article","venue":"Biomedicines","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; W. Garfield Weston Foundation; Weston Family Foundation; Consortium canadien en neurodégénérescence associée au vieillissement; Compute Canada","keywords":"Epitope; Synucleinopathies; Fibril; Chemistry; Monoclonal antibody; Thioflavin; Alpha-synuclein; Dementia with Lewy bodies; Neurotoxicity; Biochemistry; Conformational change; Biophysics; Antibody; Cell biology; Biology; Parkinson's disease; Alzheimer's disease; Immunology; Toxicity; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002962326,0.0004755235,0.0002864868,0.000176283,0.0001008588,0.0003391925,0.0004519554,0.0003828817,0.0004755691],"category_scores_gemma":[0.0003469743,0.0002386231,0.0002410603,0.0001868843,0.0001398047,0.0002115345,0.0002145358,0.0005537748,0.0002457513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004365043,"about_ca_system_score_gemma":0.0002418138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003575171,"about_ca_topic_score_gemma":0.0005914081,"domain_scores_codex":[0.9998683,0.00002623234,0.00001087843,0.00002290034,0.0000370957,0.00003467037],"domain_scores_gemma":[0.9999137,0.00001890641,0.00002253214,0.000007599381,0.00002227771,0.00001493229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009424874,0.0001388017,0.0002068372,0.00009966316,0.00001897995,0.000113943,0.00002178843,0.003525508,0.9878853,0.0007469963,0.0002675748,0.00688056],"study_design_scores_gemma":[0.0001413097,0.001218808,0.0007203208,0.00002254449,0.00006036549,0.0004316945,0.00002094059,0.01911295,0.9670854,0.0003044762,0.0108669,0.00001421505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9446574,0.003679511,0.04607083,0.0002930946,0.00009926262,0.0003329409,0.0003628885,0.000256035,0.004248085],"genre_scores_gemma":[0.9580494,0.002627932,0.03642396,0.0002240327,0.00001767541,0.0001510886,0.0007115992,0.00004084302,0.001753472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004755691,"threshold_uncertainty_score":0.003167033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03854178177110486,"score_gpt":0.295791269962786,"score_spread":0.2572494881916812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}