{"id":"W4294990888","doi":"10.1242/dmm.049703","title":"Targeting firing rate neuronal homeostasis can prevent seizures","year":2022,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Directorate for Biological Sciences; National Institutes of Health; Vrije Universiteit Brussel; Epilepsy Research UK; Medical Research Council Canada; University of Manchester; Wellcome Trust","keywords":"Homeostasis; Neuroscience; Neuronal firing; Biology; Cell biology; Electrophysiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009052367,0.0003812688,0.0002604503,0.000250057,0.0001167145,0.0002616297,0.0002134913,0.0002659378,0.0009502098],"category_scores_gemma":[0.00009805666,0.00009444262,0.0001993346,0.0001093748,0.0002196353,0.0002395642,0.0001648662,0.0006047232,0.0001926583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002497839,"about_ca_system_score_gemma":0.0001747792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004665838,"about_ca_topic_score_gemma":0.001393843,"domain_scores_codex":[0.9999104,0.00001045109,0.00001079482,0.00002052846,0.0000284876,0.00001934104],"domain_scores_gemma":[0.9999403,0.000007561542,0.00002798154,0.000006787386,0.00000578937,0.00001148553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005335208,0.00001659842,0.00008978106,0.00002721608,0.000003098751,0.00001783421,0.000004719505,0.00005300979,0.9977393,0.0001133657,0.00002888848,0.001852864],"study_design_scores_gemma":[0.00001993892,0.000657935,0.003115157,0.00001198597,0.00001950492,0.0001264208,0.00001524366,0.0006461401,0.9930645,0.0001030074,0.002214965,0.000005313359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877558,0.002552226,0.00567905,0.0002143114,0.00005379571,0.00006951956,0.000442488,0.0003514122,0.002881326],"genre_scores_gemma":[0.9915244,0.002491517,0.003566246,0.00007097073,0.00001149564,0.00006221735,0.0002776254,0.00002873823,0.001966847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009502098,"threshold_uncertainty_score":0.003178775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05772978677665803,"score_gpt":0.3090913930500734,"score_spread":0.2513616062734154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}