{"id":"W4294991228","doi":"10.1002/ejhf.2675","title":"Biomarkers in heart failure clinical trials. A review from the Biomarkers Working Group of the Heart Failure Association of the European Society of Cardiology","year":2022,"lang":"en","type":"review","venue":"European Journal of Heart Failure","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Surgical Specialties (Canada)","funders":"","keywords":"Medicine; Clinical trial; Clinical endpoint; Heart failure; Surrogate endpoint; Biomarker; Intensive care medicine; Biomarker discovery; Valsartan; Endpoint Determination; Randomized controlled trial; Clinical study design; Internal medicine; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01414637,0.001892328,0.004198522,0.004946551,0.0004443814,0.00269037,0.00219196,0.004353353,0.004891044],"category_scores_gemma":[0.01887932,0.0007407343,0.002747778,0.005401277,0.001044491,0.002911774,0.001559142,0.003855329,0.002676472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002193315,"about_ca_system_score_gemma":0.005020849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001787065,"about_ca_topic_score_gemma":0.003439674,"domain_scores_codex":[0.9929665,0.003211878,0.001609671,0.0005051271,0.001484934,0.0002217807],"domain_scores_gemma":[0.98137,0.01233006,0.00236783,0.0002967524,0.003173864,0.0004615087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004516925,0.0000447843,0.0002445155,0.09269236,0.0007322232,0.00009990924,0.00008593155,0.0001716416,0.0003384498,0.003042849,0.1226142,0.7794815],"study_design_scores_gemma":[0.0004208334,0.0002284501,0.001589653,0.1133749,0.001587895,0.0005193906,0.00006247331,0.000132584,0.0002320636,0.003920439,0.8778843,0.00004710874],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002144997,0.9972372,0.0001447457,0.001460072,0.0007891323,0.00003407595,0.00005714512,0.000008202698,0.0002478632],"genre_scores_gemma":[0.0005154214,0.9930334,0.0008059575,0.004069433,0.0008935236,0.0001630132,0.0001669086,0.000008648904,0.0003437876],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01414637,"threshold_uncertainty_score":0.07481408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1054669469037981,"score_gpt":0.3619022255974795,"score_spread":0.2564352786936813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}