{"id":"W4294992363","doi":"10.1161/circulationaha.121.058901","title":"ATIC-Associated De Novo Purine Synthesis Is Critically Involved in Proliferative Arterial Disease","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institutes of Health Research","funders":"National Institute of General Medical Sciences; National Eye Institute; National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"Neointima; Medicine; Vascular smooth muscle; Restenosis; Purine; Purine metabolism; De novo synthesis; Biochemistry; Internal medicine; Endocrinology; Biology; Enzyme; Stent","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002307,0.0004943994,0.000296839,0.0005007996,0.0002634088,0.000474268,0.0002270748,0.0005065977,0.0009959689],"category_scores_gemma":[0.0002479264,0.000122922,0.0002499045,0.0002419125,0.0004115078,0.000173107,0.000240376,0.0004731414,0.0002108778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002986185,"about_ca_system_score_gemma":0.000228709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002533906,"about_ca_topic_score_gemma":0.0002066363,"domain_scores_codex":[0.999828,0.00002122757,0.00001283212,0.00006059221,0.00004526865,0.00003197428],"domain_scores_gemma":[0.9996001,0.00003698425,0.0001904911,0.00002642172,0.00004906761,0.0000968378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005238978,0.00004221084,0.006042819,0.0001474908,0.00003385183,0.0006243244,0.00003242649,0.00008801909,0.9873121,0.0003520168,0.0001862195,0.004614655],"study_design_scores_gemma":[0.00006901198,0.001112228,0.2282135,0.0000779858,0.0003376415,0.006641332,0.0001569393,0.00286763,0.7427761,0.001198149,0.01650478,0.00004465239],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9701834,0.01948485,0.006524662,0.0003150999,0.0001008606,0.00004649351,0.000777721,0.0002494053,0.002317574],"genre_scores_gemma":[0.9935283,0.003133065,0.001672857,0.00009756169,0.0000587056,0.00002983681,0.000469525,0.00001527849,0.0009947307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009959689,"threshold_uncertainty_score":0.00333184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01537954790945366,"score_gpt":0.2684262335325925,"score_spread":0.2530466856231389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}