{"id":"W4294993159","doi":"10.1016/j.sbi.2022.102448","title":"Mass spectrometry-based shotgun glycomics for discovery of natural ligands of glycan-binding proteins","year":2022,"lang":"en","type":"review","venue":"Current Opinion in Structural Biology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Glycan; Glycomics; Computational biology; Interactome; Chemistry; Biochemistry; Glycobiology; Biology; Glycoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003487485,0.0004304474,0.001236117,0.0005646987,0.00007414191,0.00001793369,0.0006675389,0.0003908323,0.00006292771],"category_scores_gemma":[0.0003901809,0.0003541714,0.0006443076,0.0005244763,0.0002306774,0.000008401321,0.0002615958,0.0005346912,7.410554e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001244563,"about_ca_system_score_gemma":0.000573009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001593395,"about_ca_topic_score_gemma":0.000004891581,"domain_scores_codex":[0.9974894,0.0002188244,0.001005383,0.0006094152,0.0002134687,0.0004635107],"domain_scores_gemma":[0.9984375,0.0001567738,0.0007347605,0.0005134863,0.0000976668,0.00005985865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001647378,0.0002462069,0.001307629,0.06825559,0.0006075989,0.000002953002,0.00006022069,0.0000701126,0.07111374,0.00571092,0.000470807,0.8505068],"study_design_scores_gemma":[0.001753428,0.001174053,0.00003590075,0.001845946,0.00006407704,0.00003264157,0.000032202,0.0001616572,0.009676099,0.0003368762,0.9842226,0.0006645554],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008445143,0.9823571,0.0009825206,0.0000187825,0.003865281,0.002328155,0.001969947,0.000008603649,0.000024425],"genre_scores_gemma":[0.01697075,0.9636116,0.001247639,0.00000341531,0.0005327459,0.0005215894,0.01699597,0.00005924611,0.00005705493],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9837518,"threshold_uncertainty_score":0.999891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07292344986823798,"score_gpt":0.4064805516340728,"score_spread":0.3335571017658349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}