{"id":"W4295004843","doi":"10.1038/s41467-022-32986-7","title":"Germline-somatic JAK2 interactions are associated with clonal expansion in myelofibrosis","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Federal Office of Rural Health Policy; Office of Naval Research; Medical Research Council; U.S. Public Health Service; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services; British Heart Foundation; Wellcome Trust; U.S. Department of Defense","keywords":"Myelofibrosis; Germline; Myeloproliferative neoplasm; Biology; Germline mutation; Somatic cell; Genetics; Myeloid; Mutation; Essential thrombocythemia; Cancer research; Gene; Bone marrow; Immunology; Polycythemia vera","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002069029,0.0001442073,0.00009841863,0.0006106275,0.0001921024,0.0002424817,0.0001380486,0.00021985,0.001195352],"category_scores_gemma":[0.0009195068,0.00007750232,0.00009507759,0.0003141653,0.0001543094,0.0001036681,0.0001817916,0.0001827138,0.00008189199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001238848,"about_ca_system_score_gemma":0.0000829737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004805232,"about_ca_topic_score_gemma":0.0008735874,"domain_scores_codex":[0.9998529,0.00002943205,0.00001161556,0.00002851703,0.00005479943,0.00002274485],"domain_scores_gemma":[0.9994821,0.0001201037,0.0002666841,0.0000225956,0.00003904241,0.0000694519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003224499,0.00004989633,0.9373686,0.00002677723,0.00005192244,0.001850129,0.00008318662,0.0002348369,0.0444671,0.0001376202,0.0002083714,0.01519917],"study_design_scores_gemma":[0.00001123845,0.0001277789,0.9855741,0.000009925174,0.00003965268,0.007336848,0.00006663182,0.0005162307,0.005725275,0.0001724243,0.0004147202,0.00000528598],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993006,0.0002065065,0.0001404546,0.00002223152,0.000001681225,0.000002352982,0.00004648176,0.00000781927,0.0002718269],"genre_scores_gemma":[0.9997461,0.00003821292,0.0001237462,0.000007424052,0.000003623954,9.61847e-7,0.00003668374,0.000001298641,0.00004195792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001195352,"threshold_uncertainty_score":0.003998816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02653194971283095,"score_gpt":0.3141267671783516,"score_spread":0.2875948174655207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}