{"id":"W4295008295","doi":"10.1016/j.mcpro.2022.100411","title":"The in vivo Interaction Landscape of Histones H3.1 and H3.3","year":2022,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; SickKids Foundation; Princess Margaret Cancer Centre; Hospital for Sick Children","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Cure Starts Now Foundation; Canadian Cancer Society; ChadTough Foundation","keywords":"Chromatin; Histone H3; Biology; Histone; Histone code; Replication timing; Cell biology; Interactome; Computational biology; DNA replication; Genetics; Histone H2A; Nucleosome; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001885233,0.0001718255,0.0001422568,0.0002375234,0.0003763795,0.0004412832,0.0001993541,0.0003119522,0.0009842325],"category_scores_gemma":[0.0002611893,0.0001755508,0.0001481882,0.0002248179,0.0002749436,0.0003165386,0.0003481405,0.0003204379,0.0003755549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003579142,"about_ca_system_score_gemma":0.0002289596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001569487,"about_ca_topic_score_gemma":0.003270737,"domain_scores_codex":[0.9998192,0.00002071899,0.000005435194,0.00007136993,0.00005308505,0.00003020939],"domain_scores_gemma":[0.9998819,0.00003234866,0.00003479616,0.0000152691,0.00001646408,0.00001919405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006231385,0.000004442962,0.002279003,0.00001818023,0.0000104111,0.00001964624,0.00001959818,0.00005118143,0.9958496,0.000194221,0.00003470118,0.001456587],"study_design_scores_gemma":[0.000005799146,0.00006675747,0.05341567,0.000004442325,0.00003078307,0.0003741637,0.0001079601,0.001633242,0.9401252,0.0004704823,0.003756042,0.000009445675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9718513,0.002904076,0.02233683,0.0001539136,0.00001728685,0.00001089758,0.0006220106,0.00008537272,0.002018338],"genre_scores_gemma":[0.9929898,0.0006544715,0.004529514,0.00007038088,0.000007386217,0.0000128235,0.0004793242,0.00002560082,0.001230723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001569487,"threshold_uncertainty_score":0.003292561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004176986097677608,"score_gpt":0.2048743735925271,"score_spread":0.2006973874948495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}