{"id":"W4295008295","doi":"10.1016/j.mcpro.2022.100411","title":"The in vivo Interaction Landscape of Histones H3.1 and H3.3","year":2022,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; SickKids Foundation; Princess Margaret Cancer Centre; Hospital for Sick Children","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Cure Starts Now Foundation; Canadian Cancer Society; ChadTough Foundation","keywords":"Chromatin; Histone H3; Biology; Histone; Histone code; Replication timing; Cell biology; Interactome; Computational biology; DNA replication; Genetics; Histone H2A; Nucleosome; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000261356,0.0001145384,0.0001210165,0.00004405804,0.0002005385,0.00001266255,0.0001444195,0.00008073773,0.00001237057],"category_scores_gemma":[0.00003137044,0.00009446434,0.00006564932,0.00009747838,0.0001010008,0.000001952078,0.0002992722,0.000206448,6.53862e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001903553,"about_ca_system_score_gemma":0.0000302709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003097954,"about_ca_topic_score_gemma":0.00001928429,"domain_scores_codex":[0.9991642,0.0001236801,0.000204087,0.0002275163,0.0001170963,0.0001634083],"domain_scores_gemma":[0.9996074,0.000009246293,0.0001021236,0.0002259609,0.00002980694,0.00002550594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001020815,0.00004588435,0.0008035516,0.0000165786,0.00005007374,0.00001242351,0.0001306503,0.0002604994,0.9975325,0.0002128078,0.0003456074,0.0004873631],"study_design_scores_gemma":[0.0004145316,0.0001863118,0.000113672,0.000006830586,0.0000154142,0.00002292695,0.0004997434,0.000326653,0.9634005,0.0001104164,0.03478058,0.0001224448],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892563,0.0085169,0.0004137755,0.0003721449,0.0001929537,0.0003068535,0.000008650809,0.000005827984,0.0009266534],"genre_scores_gemma":[0.9982613,0.0006737695,0.0003030213,0.00007567085,0.0000250527,0.00006047138,0.00001860316,0.00001867372,0.000563453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03443497,"threshold_uncertainty_score":0.3852144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004176986097677608,"score_gpt":0.2048743735925271,"score_spread":0.2006973874948495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}