{"id":"W4295016328","doi":"10.21203/rs.3.rs-1971723/v1","title":"Activation of Arcuate nucleus Glucagon-like Peptide-1 receptor-expressing neurons suppresses food intake","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health; Purdue University; National Institute of Diabetes and Digestive and Kidney Diseases; Robert Wood Johnson Foundation","keywords":"Arcuate nucleus; Glucagon-like peptide-1; Nucleus; Receptor; Food intake; Chemistry; Cell biology; Glucagon; Endocrinology; Internal medicine; Biology; Medicine; Biochemistry; Diabetes mellitus; Insulin; Type 2 diabetes","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001010347,0.0002859083,0.0004008538,0.0002266553,0.00009555058,0.0002396512,0.0003072954,0.0002619874,0.002140464],"category_scores_gemma":[0.0001342061,0.0001471716,0.0003014673,0.000100928,0.0003258571,0.0002160503,0.0002021605,0.0009959589,0.0004347376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002327303,"about_ca_system_score_gemma":0.0002086946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000365636,"about_ca_topic_score_gemma":0.0005727556,"domain_scores_codex":[0.9998416,0.00001428569,0.00001242143,0.00004568379,0.00003618958,0.00004980203],"domain_scores_gemma":[0.9998803,0.00001926767,0.00002952302,0.00001370324,0.00001356765,0.00004352114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001340926,0.00002513446,0.0001108465,0.00004455901,0.00000415291,0.000029813,0.00000949788,0.00002855053,0.9986426,0.00004989135,0.00003744816,0.000883475],"study_design_scores_gemma":[0.00003468582,0.0005361432,0.005967746,0.00001291596,0.00002466451,0.000219501,0.00006218993,0.001045865,0.989971,0.00008970557,0.002030165,0.000005470081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917349,0.001049708,0.004430888,0.0001397543,0.00009006248,0.00003258821,0.0003969412,0.0002312236,0.001893902],"genre_scores_gemma":[0.9892638,0.0008423549,0.003701595,0.0001603886,0.00002960839,0.0001401625,0.0004467001,0.00009126744,0.005324129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002140464,"threshold_uncertainty_score":0.007160544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1124899345832066,"score_gpt":0.3711876384903999,"score_spread":0.2586977039071933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}