{"id":"W4295034863","doi":"10.1136/bjsports-2021-105132","title":"Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study","year":2022,"lang":"en","type":"article","venue":"British Journal of Sports Medicine","topic":"Physical Activity and Health","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; University of British Columbia; University Hospital Foundation; McGill University; Queen's University; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; University Health Network; Centre hospitalier universitaire de Québec; Royal Victoria Hospital; University of Toronto; Institute of Cancer Research; Institute of Aging","funders":"H2020 European Research Council; National Center for Chronic Disease Prevention and Health Promotion; Servicio Gallego de Salud; Health and Medical Research Fund; Instituto de Salud Carlos III; Cancer Council Western Australia; Cancer Council Victoria; World Cancer Research Fund; Medical Research Council; Institute of Cancer Research; Canadian Cancer Society Research Institute; Manchester Biomedical Research Centre; Seventh Framework Programme; Hellenic Health Foundation; Freistaat Sachsen; Deutschen Konsortium für Translationale Krebsforschung; Ministry of Science and Higher Education of the Russian Federation; Universitätsklinikum Hamburg-Eppendorf; Xunta de Galicia; Stichting Tegen Kanker; Gesellschaft der Freunde der Medizinischen Hochschule Hannover; Mutuelle Générale de l'Education Nationale; Imperial Experimental Cancer Medicine Centre; Institut Gustave-Roussy; Ministero dello Sviluppo Economico; National Health and Medical Research Council; Deutsche Krebshilfe; Cancer Institute NSW; Medizinischen Hochschule Hannover; Karolinska Institutet; Associazione Italiana per la Ricerca sul Cancro; Fru Berta Kamprads Stiftelse; KWF Kankerbestrijding; Syöpäsäätiö; Vetenskapsrådet; Norges Forskningsråd; Stockholms Läns Landsting; University of Westminster; Ligue Contre le Cancer; Kuopion Yliopistollinen Sairaala; Gunnar Nilssons Cancerstiftelse; Daiichi-Sankyo; University of Southern California; Cancerfonden; Itä-Suomen Yliopisto; Eberhard Karls Universität Tübingen; American Cancer Society; Russian Foundation for Basic Research; Eli Lilly and Company; Consiglio Nazionale delle Ricerche; Wellcome Trust; Agence Nationale de la Recherche; Deutsche Gesetzliche Unfallversicherung; Gentofte Hospital; Deutsche Forschungsgemeinschaft; VicHealth; National Breast Cancer Foundation; McGill University Health Centre; University of Bristol; Canadian Institutes of Health Research; European Commission; Victorian Cancer Agency; Breast Cancer Now; Against Breast Cancer; University College London; Department of Health and Social Care; National Cancer Institute; European Regional Development Fund; Ministerio de Sanidad, Servicios Sociales e Igualdad; University of Cambridge; Government of Canada; Stavros Niarchos Foundation; Marshfield Clinic Research Foundation; Fondation de France; Breast Cancer Campaign; University of Utah; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; National Institute of Environmental Health Sciences; Swedish Cancer Foundation; David F. and Margaret T. Grohne Family Foundation; University Hospitals Bristol NHS Foundation Trust; University of Crete; Institut National de la Santé et de la Recherche Médicale; Programme Grants for Applied Research; Robert Bosch Stiftung; Harvard T.H. Chan School of Public Health; Huntsman Cancer Foundation; Brigham and Women's Hospital; U.S. Department of Defense; Cancer Research UK; Hamburger Krebsgesellschaft; Memorial Sloan-Kettering Cancer Center; Institut National Du Cancer; Centre International de Recherche sur le Cancer; Kreftforeningen; Sundhed og Sygdom, Det Frie Forskningsråd; NIHR Bristol Biomedical Research Centre; Deutsches Krebsforschungszentrum; Breast Cancer Research Foundation; McGill University; Centers for Disease Control and Prevention; National Institute for Health and Care Research; National Institutes of Health; Division of Cancer Prevention, National Cancer Institute; Lon V. Smith Foundation; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Oak Foundation; Leids Universitair Medisch Centrum; Myriad Genetics; Université Laval; Fondation du cancer du sein du Québec; California Department of Public Health; Celgene; University of California, San Francisco; Intermountain Healthcare; Genome Canada; Rheinische Friedrich-Wilhelms-Universität Bonn; U.S. Department of Health and Human Services; Fonds Wetenschappelijk Onderzoek; Huntsman Cancer Institute; Ministerio de Economía y Competitividad; Bundesministerium für Bildung und Forschung; Ovarian Cancer Research Fund; Pfizer; Amgen","keywords":"Breast cancer; Medicine; Physical activity; Mendelian inheritance; Sedentary lifestyle; Physical therapy; Sedentary behavior; Oncology; Cancer; Internal medicine; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03353378,0.001549806,0.002121245,0.001144012,0.0007705318,0.0009830756,0.001601607,0.001712578,0.004672779],"category_scores_gemma":[0.0685825,0.001104577,0.001994017,0.001716739,0.001097022,0.0008219954,0.0007698584,0.001142993,0.0007948917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008940669,"about_ca_system_score_gemma":0.001248677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003283816,"about_ca_topic_score_gemma":0.001977421,"domain_scores_codex":[0.9594089,0.03180989,0.002295138,0.003701246,0.002155877,0.0006288972],"domain_scores_gemma":[0.9803464,0.01039367,0.002995797,0.005098533,0.0008272268,0.0003384555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2091245,0.004070785,0.578315,0.005215686,0.03975548,0.005437207,0.003850369,0.008983302,0.008772877,0.02057356,0.01713194,0.09876934],"study_design_scores_gemma":[0.1724602,0.05374557,0.4709536,0.002036909,0.04795831,0.01761756,0.0009976558,0.1272197,0.005708513,0.05275494,0.04768022,0.0008668411],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7759588,0.007031139,0.1818453,0.001209866,0.0006508834,0.02434536,0.004800134,0.0006154581,0.003542964],"genre_scores_gemma":[0.9322072,0.0009535636,0.04403604,0.0007657351,0.0001693082,0.01723677,0.002001361,0.000103818,0.002526151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03353378,"threshold_uncertainty_score":0.1773457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0152185805421745,"score_gpt":0.3021282705756075,"score_spread":0.286909690033433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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