{"id":"W4295034863","doi":"10.1136/bjsports-2021-105132","title":"Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study","year":2022,"lang":"en","type":"article","venue":"British Journal of Sports Medicine","topic":"Physical Activity and Health","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; University of British Columbia; University Hospital Foundation; McGill University; Queen's University; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; University Health Network; Centre hospitalier universitaire de Québec; Royal Victoria Hospital; University of Toronto; Institute of Cancer Research; Institute of Aging","funders":"H2020 European Research Council; National Center for Chronic Disease Prevention and Health Promotion; Servicio Gallego de Salud; Health and Medical Research Fund; Instituto de Salud Carlos III; Cancer Council Western Australia; Cancer Council Victoria; World Cancer Research Fund; Medical Research Council; Institute of Cancer Research; Canadian Cancer Society Research Institute; Manchester Biomedical Research Centre; Seventh Framework Programme; Hellenic Health Foundation; Freistaat Sachsen; Deutschen Konsortium für Translationale Krebsforschung; Ministry of Science and Higher Education of the Russian Federation; Universitätsklinikum Hamburg-Eppendorf; Xunta de Galicia; Stichting Tegen Kanker; Gesellschaft der Freunde der Medizinischen Hochschule Hannover; Mutuelle Générale de l'Education Nationale; Imperial Experimental Cancer Medicine Centre; Institut Gustave-Roussy; Ministero dello Sviluppo Economico; National Health and Medical Research Council; Deutsche Krebshilfe; Cancer Institute NSW; Medizinischen Hochschule Hannover; Karolinska Institutet; Associazione Italiana per la Ricerca sul Cancro; Fru Berta Kamprads Stiftelse; KWF Kankerbestrijding; Syöpäsäätiö; Vetenskapsrådet; Norges Forskningsråd; Stockholms Läns Landsting; University of Westminster; Ligue Contre le Cancer; Kuopion Yliopistollinen Sairaala; Gunnar Nilssons Cancerstiftelse; Daiichi-Sankyo; University of Southern California; Cancerfonden; Itä-Suomen Yliopisto; Eberhard Karls Universität Tübingen; American Cancer Society; Russian Foundation for Basic Research; Eli Lilly and Company; Consiglio Nazionale delle Ricerche; Wellcome Trust; Agence Nationale de la Recherche; Deutsche Gesetzliche Unfallversicherung; Gentofte Hospital; Deutsche Forschungsgemeinschaft; VicHealth; National Breast Cancer Foundation; McGill University Health Centre; University of Bristol; Canadian Institutes of Health Research; European Commission; Victorian Cancer Agency; Breast Cancer Now; Against Breast Cancer; University College London; Department of Health and Social Care; National Cancer Institute; European Regional Development Fund; Ministerio de Sanidad, Servicios Sociales e Igualdad; University of Cambridge; Government of Canada; Stavros Niarchos Foundation; Marshfield Clinic Research Foundation; Fondation de France; Breast Cancer Campaign; University of Utah; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; National Institute of Environmental Health Sciences; Swedish Cancer Foundation; David F. and Margaret T. Grohne Family Foundation; University Hospitals Bristol NHS Foundation Trust; University of Crete; Institut National de la Santé et de la Recherche Médicale; Programme Grants for Applied Research; Robert Bosch Stiftung; Harvard T.H. Chan School of Public Health; Huntsman Cancer Foundation; Brigham and Women's Hospital; U.S. Department of Defense; Cancer Research UK; Hamburger Krebsgesellschaft; Memorial Sloan-Kettering Cancer Center; Institut National Du Cancer; Centre International de Recherche sur le Cancer; Kreftforeningen; Sundhed og Sygdom, Det Frie Forskningsråd; NIHR Bristol Biomedical Research Centre; Deutsches Krebsforschungszentrum; Breast Cancer Research Foundation; McGill University; Centers for Disease Control and Prevention; National Institute for Health and Care Research; National Institutes of Health; Division of Cancer Prevention, National Cancer Institute; Lon V. Smith Foundation; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Oak Foundation; Leids Universitair Medisch Centrum; Myriad Genetics; Université Laval; Fondation du cancer du sein du Québec; California Department of Public Health; Celgene; University of California, San Francisco; Intermountain Healthcare; Genome Canada; Rheinische Friedrich-Wilhelms-Universität Bonn; U.S. Department of Health and Human Services; Fonds Wetenschappelijk Onderzoek; Huntsman Cancer Institute; Ministerio de Economía y Competitividad; Bundesministerium für Bildung und Forschung; Ovarian Cancer Research Fund; Pfizer; Amgen","keywords":"Breast cancer; Medicine; Physical activity; Mendelian inheritance; Sedentary lifestyle; Physical therapy; Sedentary behavior; Oncology; Cancer; Internal medicine; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009317118,0.0001227901,0.0008100692,0.0001271356,0.0002662107,0.00001000546,0.00006819684,0.00002108249,0.0008766027],"category_scores_gemma":[0.00004122935,0.0001112317,0.00008893708,0.0002100453,0.000100901,0.0001594962,0.00006145387,0.0008222806,7.909602e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001631217,"about_ca_system_score_gemma":0.0001796842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002370878,"about_ca_topic_score_gemma":0.0000276709,"domain_scores_codex":[0.9981699,0.0001484277,0.0003214397,0.0001859824,0.0009839383,0.0001902966],"domain_scores_gemma":[0.9989235,0.00008820753,0.0004743506,0.00009375214,0.0001193389,0.0003007879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.006374442,0.007173649,0.05483779,0.00008564356,0.0003347941,0.003691555,0.002472244,0.00004625047,0.002306715,0.000002809109,0.006860645,0.9158134],"study_design_scores_gemma":[0.01763189,0.001791231,0.9659791,0.0006780291,0.000718062,0.01111361,0.001041248,0.0003850231,0.00003825686,0.000222686,0.0002867701,0.0001140967],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939129,0.0007347158,0.000007544165,0.004432545,0.0001925625,0.0005082227,0.00005551894,0.00001399339,0.0001420206],"genre_scores_gemma":[0.9967867,0.001366329,0.00001032504,0.0002971536,0.001302539,0.00001301202,0.000006368147,0.00001813013,0.0001995019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9156994,"threshold_uncertainty_score":0.9598185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0152185805421745,"score_gpt":0.3021282705756075,"score_spread":0.286909690033433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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