{"id":"W4295037734","doi":"10.1111/ejn.15817","title":"Astrocytes show increased levels of Ero1α in multiple sclerosis and its experimental autoimmune encephalomyelitis animal model","year":2022,"lang":"en","type":"article","venue":"European Journal of Neuroscience","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Institute of Genetics; Natural Sciences and Engineering Research Council of Canada; Multiple Sclerosis Society of Canada; Campus Alberta Neuroscience","keywords":"Experimental autoimmune encephalomyelitis; Multiple sclerosis; Inflammation; Reactive oxygen species; Oxidative stress; Context (archaeology); Unfolded protein response; Microglia; Endoplasmic reticulum; Encephalomyelitis; Immunology; Cell biology; Astrocyte; Central nervous system; Chemistry; Biology; Neuroscience; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000130139,0.0003752593,0.00036523,0.0005051178,0.0003055111,0.0002614965,0.0001036808,0.0004161052,0.00125136],"category_scores_gemma":[0.00009107513,0.0001655535,0.000249793,0.0003144023,0.0002500389,0.0002577475,0.0002159214,0.0008398099,0.0005935964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001526025,"about_ca_system_score_gemma":0.0001371089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005057479,"about_ca_topic_score_gemma":0.0008876463,"domain_scores_codex":[0.9998023,0.00002048511,0.00002301337,0.00004957618,0.00006746985,0.00003725229],"domain_scores_gemma":[0.9998736,0.00000427208,0.00004058544,0.000009840522,0.0000343984,0.00003722973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004156409,0.00005418433,0.0007846673,0.00009757775,0.00001534216,0.0002653642,0.00007636159,0.00002164538,0.9966253,0.00007294247,0.00007871707,0.001492342],"study_design_scores_gemma":[0.00006296607,0.001249368,0.04135701,0.00005745529,0.0001253869,0.002814816,0.00043042,0.0005111566,0.9427752,0.0005884883,0.01000783,0.0000198603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820715,0.00781557,0.004366273,0.0003660866,0.0002627147,0.00005188381,0.0009061252,0.000185195,0.003974573],"genre_scores_gemma":[0.9800287,0.004592093,0.004063223,0.0002366194,0.00007452579,0.0001256753,0.0008460864,0.0000379197,0.009995091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00125136,"threshold_uncertainty_score":0.004186273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04191187531898959,"score_gpt":0.2463032355764472,"score_spread":0.2043913602574576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}