{"id":"W4295037899","doi":"10.1371/journal.ppat.1010835","title":"TREX (transcription/export)-NP complex exerts a dual effect on regulating polymerase activity and replication of influenza A virus","year":2022,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"State Key Laboratory of Veterinary Biotechnology; National Natural Science Foundation of China; University of Ottawa; National Key Research and Development Program of China; University of Wisconsin-Madison","keywords":"Biology; Viral replication; Polymerase; Gene knockdown; Influenza A virus; Transcription (linguistics); Cell biology; Viral protein; Viral structural protein; RNA polymerase II; RNA polymerase; Virus; Nuclear export signal; Viral entry; Virology; RNA; Gene; Gene expression; Genetics; Promoter","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001338243,0.000363286,0.0002878743,0.00009914186,0.0001516658,0.0003292638,0.0001493449,0.0001999252,0.001430552],"category_scores_gemma":[0.0001064041,0.0001540505,0.0002294227,0.00005596828,0.0001742053,0.0002302477,0.00020772,0.0003955058,0.0003323852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002224757,"about_ca_system_score_gemma":0.0001220439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003730486,"about_ca_topic_score_gemma":0.0005780419,"domain_scores_codex":[0.9998369,0.00002224945,0.00001778628,0.00005064462,0.00004056131,0.00003183627],"domain_scores_gemma":[0.9999332,0.000009075777,0.00001855425,0.000009954891,0.000008686884,0.00002042467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000053869,0.000006574552,0.00007773531,0.00002102908,0.00000248528,0.00001534262,0.000003104121,0.00001514936,0.9995055,0.00002313468,0.00001095946,0.0002651358],"study_design_scores_gemma":[0.000008865132,0.000112861,0.002791562,0.000003164142,0.000006446944,0.0001105808,0.00001082563,0.0005419741,0.9954537,0.00001798792,0.0009397368,0.000002272827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917392,0.003500748,0.002716699,0.00007577778,0.00005046493,0.00002203002,0.0003972782,0.00007900433,0.001418708],"genre_scores_gemma":[0.9940294,0.0007597535,0.002011808,0.0000463881,0.00001344185,0.00002039455,0.0004295637,0.0000185544,0.00267067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001430552,"threshold_uncertainty_score":0.004785657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1101807525708813,"score_gpt":0.3611323851967555,"score_spread":0.2509516326258742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}