{"id":"W4295037899","doi":"10.1371/journal.ppat.1010835","title":"TREX (transcription/export)-NP complex exerts a dual effect on regulating polymerase activity and replication of influenza A virus","year":2022,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"State Key Laboratory of Veterinary Biotechnology; National Natural Science Foundation of China; University of Ottawa; National Key Research and Development Program of China; University of Wisconsin-Madison","keywords":"Biology; Viral replication; Polymerase; Gene knockdown; Influenza A virus; Transcription (linguistics); Cell biology; Viral protein; Viral structural protein; RNA polymerase II; RNA polymerase; Virus; Nuclear export signal; Viral entry; Virology; RNA; Gene; Gene expression; Genetics; Promoter","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006709566,0.0002131153,0.0004917839,0.000242898,0.000414006,0.00001217366,0.00007275227,0.00005183552,0.0001702125],"category_scores_gemma":[0.0006434602,0.0001969719,0.0001208745,0.0003439214,0.0001487352,0.00007600311,0.0001507067,0.0003199562,0.00000626892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001575389,"about_ca_system_score_gemma":0.00006710743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001203954,"about_ca_topic_score_gemma":0.00001037884,"domain_scores_codex":[0.9976514,0.0003403117,0.000352435,0.0005391343,0.0007827909,0.0003339199],"domain_scores_gemma":[0.9985875,0.0002780834,0.0001879173,0.0007008409,0.0001050786,0.0001405293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0019166,0.0004692429,0.0173074,0.0002351391,0.0001611579,0.00005275503,0.001189778,0.00001767386,0.9650097,0.00004651426,0.0001991703,0.0133949],"study_design_scores_gemma":[0.004304032,0.004210759,0.3450959,0.0001328643,0.0003007139,0.00009637849,0.0002245031,0.001392187,0.6415543,0.00003574915,0.00232939,0.0003232162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970715,0.0003644066,0.000007642154,0.0002965892,0.00002810705,0.001042648,0.0003157869,0.00008979165,0.0007835489],"genre_scores_gemma":[0.9985577,0.00002424372,0.0001692424,0.0006477115,0.00006730224,0.0003576096,0.00003884999,0.00003569873,0.0001016586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3277885,"threshold_uncertainty_score":0.803228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1101807525708813,"score_gpt":0.3611323851967555,"score_spread":0.2509516326258742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}