{"id":"W4295047803","doi":"10.1101/2022.09.09.22279773","title":"Genetic Risk Factors for ME/CFS Identified using Combinatorial Analysis","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Fibromyalgia and Chronic Fatigue Syndrome Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Medical Research Council; University of Edinburgh","keywords":"Chronic fatigue syndrome; Fibromyalgia; Cohort; Medicine; Biobank; Disease; Single-nucleotide polymorphism; Population; Bioinformatics; Genetics; Biology; Psychiatry; Internal medicine; Gene; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002038794,0.0005473833,0.0006636743,0.002755703,0.0007438819,0.001412445,0.0005688602,0.0004277146,0.003226857],"category_scores_gemma":[0.006439518,0.0002715352,0.001736114,0.002202268,0.000795424,0.0002735278,0.001090525,0.0004958672,0.0002429543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003141826,"about_ca_system_score_gemma":0.0004183438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00237277,"about_ca_topic_score_gemma":0.002855778,"domain_scores_codex":[0.997717,0.0007883258,0.0001454369,0.0009746132,0.0002468488,0.0001278521],"domain_scores_gemma":[0.9949054,0.002994698,0.000961819,0.0006970165,0.0001965118,0.000244599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001841829,0.0001734544,0.9061304,0.0002579646,0.003953598,0.001051329,0.0003213917,0.01033458,0.03798436,0.001621212,0.000846153,0.03548372],"study_design_scores_gemma":[0.0002668079,0.0006404896,0.9199013,0.00006177914,0.002541649,0.001890826,0.0002810742,0.05858194,0.007546519,0.00642947,0.001751024,0.0001071927],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9726959,0.0002903579,0.02422376,0.00009139817,0.00001569815,0.00007817745,0.00173857,0.00023387,0.0006324627],"genre_scores_gemma":[0.991719,0.00003692814,0.007046767,0.00004117212,0.00001392812,0.00005221437,0.0009517119,0.00002736269,0.0001109365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003226857,"threshold_uncertainty_score":0.01079488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05440159350365058,"score_gpt":0.3472816018740497,"score_spread":0.2928800083703991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}