{"id":"W4295067327","doi":"10.1161/svin.122.000447","title":"AcT Trial: Protocol for a Pragmatic Registry‐Linked Randomized Clinical Trial","year":2022,"lang":"en","type":"article","venue":"Stroke Vascular and Interventional Neurology","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of British Columbia; Toronto Western Hospital; London Health Sciences Centre; University of Ottawa; McMaster University; Hamilton Health Sciences; St. Michael's Hospital; Sunnybrook Health Science Centre; Kelowna General Hospital; Western University; University of Toronto; Medicine Hat Regional Hospital; Université de Sherbrooke; Queen's University; University of Calgary; Centre Hospitalier de l’Université de Montréal; Université de Montréal; Red Deer Regional Hospital; Ontario Brain Institute; University of Saskatchewan; Queen Elizabeth II Health Sciences Centre; Grey Nuns Community Hospital; Fraser Health; University of Alberta","funders":"University of Alberta; Heart and Stroke Foundation of Canada","keywords":"Medicine; Tenecteplase; Thrombolysis; Modified Rankin Scale; Clinical endpoint; Stroke (engine); Randomized controlled trial; Clinical trial; Fibrinolytic agent; Intracerebral hemorrhage; Tissue plasminogen activator; Anesthesia; Internal medicine; Myocardial infarction; Ischemia; Ischemic stroke; Subarachnoid hemorrhage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05092828,0.007193914,0.009183175,0.002457394,0.003551382,0.00630271,0.003601862,0.006817943,0.1585422],"category_scores_gemma":[0.05855704,0.003413243,0.005607648,0.00414279,0.003608383,0.003853368,0.002672855,0.01057991,0.03327662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005868531,"about_ca_system_score_gemma":0.01553458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001873964,"about_ca_topic_score_gemma":0.003367832,"domain_scores_codex":[0.9575295,0.03051801,0.004023024,0.00303332,0.002802036,0.002094107],"domain_scores_gemma":[0.9743994,0.007007447,0.00436786,0.00590241,0.005674273,0.002648515],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7157936,0.005909654,0.001117232,0.04853537,0.00398175,0.0004537262,0.0006228504,0.003914015,0.002003532,0.01817362,0.1541523,0.04534243],"study_design_scores_gemma":[0.8089467,0.009909158,0.001714073,0.008731493,0.001208583,0.0001547575,0.0002017419,0.004507972,0.001047195,0.0100183,0.1533531,0.0002068609],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.0007056381,0.0002085901,0.002449815,0.000357113,0.0007907419,0.989309,0.004366882,0.0001983636,0.001613834],"genre_scores_gemma":[0.001105232,0.00008908168,0.002694824,0.0002255152,0.00008357108,0.994512,0.0006516585,0.00002195348,0.0006162431],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.1585422,"threshold_uncertainty_score":0.5303764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0518791184079767,"score_gpt":0.3891398693032034,"score_spread":0.3372607508952267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}