{"id":"W4295067327","doi":"10.1161/svin.122.000447","title":"AcT Trial: Protocol for a Pragmatic Registry‐Linked Randomized Clinical Trial","year":2022,"lang":"en","type":"article","venue":"Stroke Vascular and Interventional Neurology","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of British Columbia; Toronto Western Hospital; London Health Sciences Centre; University of Ottawa; McMaster University; Hamilton Health Sciences; St. Michael's Hospital; Sunnybrook Health Science Centre; Kelowna General Hospital; Western University; University of Toronto; Medicine Hat Regional Hospital; Université de Sherbrooke; Queen's University; University of Calgary; Centre Hospitalier de l’Université de Montréal; Université de Montréal; Red Deer Regional Hospital; Ontario Brain Institute; University of Saskatchewan; Queen Elizabeth II Health Sciences Centre; Grey Nuns Community Hospital; Fraser Health; University of Alberta","funders":"University of Alberta; Heart and Stroke Foundation of Canada","keywords":"Medicine; Tenecteplase; Thrombolysis; Modified Rankin Scale; Clinical endpoint; Stroke (engine); Randomized controlled trial; Clinical trial; Fibrinolytic agent; Intracerebral hemorrhage; Tissue plasminogen activator; Anesthesia; Internal medicine; Myocardial infarction; Ischemia; Ischemic stroke; Subarachnoid hemorrhage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004227689,0.0002148418,0.001035624,0.000163351,0.0001597525,0.00002348692,0.0002035115,0.000116227,0.0009898846],"category_scores_gemma":[0.002071432,0.0001815037,0.0019574,0.00008251594,0.0002411604,0.00004395717,0.0003524083,0.0005423679,0.000005360906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002769799,"about_ca_system_score_gemma":0.0001070485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009768424,"about_ca_topic_score_gemma":0.000001164572,"domain_scores_codex":[0.9960642,0.001366077,0.001257278,0.0005785355,0.000438702,0.0002951692],"domain_scores_gemma":[0.9980069,0.0009100869,0.0004720999,0.000418355,0.00007218966,0.0001203962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9632146,0.001299126,0.0001205212,0.000233236,0.001113779,0.00002694708,0.00001225078,0.000005576615,0.00002428032,0.0009916157,0.03193912,0.001018889],"study_design_scores_gemma":[0.7052741,0.01142085,0.0001381231,0.00001707685,0.0004266813,0.00006044526,0.00001191056,0.001377132,0.000004441509,0.0002603668,0.2809139,0.00009494779],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.2004183,0.0001167955,0.01621866,0.01217521,0.002409561,0.7634939,0.0001522404,0.0002032819,0.004812025],"genre_scores_gemma":[0.04850255,0.000009352268,0.00183449,0.002612663,0.001076295,0.9405556,0.0002604903,0.00006344521,0.005085149],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.2579405,"threshold_uncertainty_score":0.9999233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0518791184079767,"score_gpt":0.3891398693032034,"score_spread":0.3372607508952267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}