{"id":"W4295073600","doi":"10.1007/s43440-022-00409-5","title":"Neuroendocrine microRNAs linked to energy homeostasis: future therapeutic potential","year":2022,"lang":"en","type":"review","venue":"Pharmacological Reports","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Energy homeostasis; Crosstalk; microRNA; Biology; Glucose homeostasis; Leptin; Neuroscience; Homeostasis; Hypothalamus; Signal transduction; Central nervous system; Hormone; Endocrinology; Bioinformatics; Insulin; Insulin resistance; Cell biology; Obesity; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007087495,0.001199359,0.001566796,0.001081383,0.0002194864,0.001328251,0.0009658111,0.001560293,0.003735933],"category_scores_gemma":[0.0009001027,0.0002665005,0.0004030149,0.001225878,0.0007460297,0.001464784,0.0008390161,0.002599282,0.001849486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005133029,"about_ca_system_score_gemma":0.0008501455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003781969,"about_ca_topic_score_gemma":0.001027853,"domain_scores_codex":[0.9998472,0.0000323263,0.00002391203,0.00003130189,0.00004508387,0.00002022207],"domain_scores_gemma":[0.9996418,0.0002037898,0.00004170573,0.00001063259,0.00006133433,0.00004077098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002135678,0.00009383378,0.0001912933,0.00962662,0.000101923,0.0003384528,0.00005500527,0.0004245843,0.005037702,0.004958214,0.03586962,0.9430891],"study_design_scores_gemma":[0.00006273983,0.0001518044,0.0008726677,0.002228854,0.0001655514,0.001277596,0.00007930922,0.0001992568,0.0009814437,0.004059637,0.9898869,0.00003421995],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001007273,0.998002,0.0002469965,0.0003925719,0.0004971138,0.000003196442,0.0000144092,0.00001020158,0.0007328619],"genre_scores_gemma":[0.0008821455,0.9969901,0.0003574685,0.0003988467,0.0007099693,0.000009488079,0.00003605418,0.000002565112,0.0006134207],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003735933,"threshold_uncertainty_score":0.0124979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08174764516586239,"score_gpt":0.3603999458233391,"score_spread":0.2786523006574767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}