{"id":"W4295084519","doi":"10.1182/bloodadvances.2022007947","title":"Clinicogenomic associations in childhood Langerhans cell histiocytosis: an international cohort study","year":2022,"lang":"en","type":"article","venue":"Blood Advances","topic":"Histiocytic Disorders and Treatments","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Universiteit Leiden; Leids Universitair Medisch Centrum; Histiocytosis Association","keywords":"Langerhans cell histiocytosis; Histiocytosis; Cohort; Medicine; Cohort study; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005612029,0.0004815526,0.0004231974,0.001054818,0.0005542036,0.0007260809,0.0004003831,0.000420343,0.001491206],"category_scores_gemma":[0.001016262,0.0003446989,0.0005795548,0.001684311,0.0003046342,0.0004335298,0.0007271244,0.0005551857,0.0002085185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003827749,"about_ca_system_score_gemma":0.0003736225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01011851,"about_ca_topic_score_gemma":0.01120123,"domain_scores_codex":[0.9994204,0.00009577549,0.00004293913,0.0002595718,0.0000649377,0.0001165049],"domain_scores_gemma":[0.999171,0.0000898373,0.0002792783,0.0001847011,0.00009263363,0.0001824378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00006801646,0.00001707432,0.9986254,0.000005218871,0.00006839973,0.0001458465,0.00009465737,0.00003581424,0.0003076355,0.00001923615,0.00006198737,0.0005507248],"study_design_scores_gemma":[0.000004446027,0.00004794974,0.9990602,0.000003065438,0.00005052301,0.0004100087,0.0001616581,0.00006468465,0.00004240271,0.000008424213,0.000142962,0.000003707571],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990396,0.0001239542,0.00006938646,0.00001150925,0.000002485756,0.000007022825,0.0004752987,0.000002521679,0.0002681128],"genre_scores_gemma":[0.9990811,0.0001267715,0.00007147481,0.00001154762,0.000004704708,0.000009023538,0.000626513,0.000003548977,0.00006511294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01011851,"threshold_uncertainty_score":0.02011925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01135229235169421,"score_gpt":0.2951635525546391,"score_spread":0.2838112602029448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}