{"id":"W4295084519","doi":"10.1182/bloodadvances.2022007947","title":"Clinicogenomic associations in childhood Langerhans cell histiocytosis: an international cohort study","year":2022,"lang":"en","type":"article","venue":"Blood Advances","topic":"Histiocytic Disorders and Treatments","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Universiteit Leiden; Leids Universitair Medisch Centrum; Histiocytosis Association","keywords":"Langerhans cell histiocytosis; Histiocytosis; Cohort; Medicine; Cohort study; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001860243,0.00009923879,0.0002140315,0.0001173035,0.000143526,0.00001166324,0.0001246523,0.00001828306,0.0003387883],"category_scores_gemma":[0.00003808475,0.000100505,0.00005026353,0.0001467704,0.00001407954,0.0001168156,0.00004710507,0.0001404981,0.00002002621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001978024,"about_ca_system_score_gemma":0.0001022912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001453505,"about_ca_topic_score_gemma":0.0002960981,"domain_scores_codex":[0.9989628,0.00006355115,0.0002529108,0.00028299,0.0002936063,0.0001441448],"domain_scores_gemma":[0.9995919,0.00003310298,0.0001044017,0.0001862921,0.00002730993,0.0000570339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002831943,0.01010101,0.9865434,0.000002717758,0.0001307123,0.00007189246,0.0008733699,0.0001286281,0.00002471248,0.00002255271,0.00003992581,0.002032822],"study_design_scores_gemma":[0.00515048,0.0008413932,0.9838642,0.000005134006,0.0002614817,0.00001014246,0.001979038,0.00003323436,0.00003142002,0.00007834456,0.007639608,0.0001055653],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861678,0.0007159183,0.000002807168,0.0001220429,0.0003000256,0.0006452844,0.0001328016,0.00004381027,0.01186947],"genre_scores_gemma":[0.9976421,0.0001091727,0.0002403908,0.0001655742,0.00007002139,0.0003068935,0.0003047207,0.00001588562,0.00114525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01147425,"threshold_uncertainty_score":0.4098473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01135229235169421,"score_gpt":0.2951635525546391,"score_spread":0.2838112602029448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}