{"id":"W4295087975","doi":"10.3390/molecules27175720","title":"6-Formyl Umbelliferone, a Furanocoumarin from Angelica decursiva L., Inhibits Key Diabetes-Related Enzymes and Advanced Glycation End-Product Formation","year":2022,"lang":"en","type":"article","venue":"Molecules","topic":"Natural Antidiabetic Agents Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Alberta Children's Hospital; University of Calgary","funders":"National Institute of Biological Resources; Ministry of Education, India; Ministry of Science and ICT, South Korea; National Research Foundation of Korea; Ministry of Environment; National Research Foundation","keywords":"Umbelliferone; Chemistry; Glycation; Biochemistry; Docking (animal); Pharmacology; Coumarin; Enzyme; Advanced glycation end-product; Small molecule; Aldose reductase; Mechanism of action; In vitro; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001322811,0.0002177346,0.000322783,0.0001287542,0.0003420046,0.00002100353,0.00009319477,0.00004741127,0.0001991229],"category_scores_gemma":[0.0001279036,0.000195532,0.0000810979,0.0003101936,0.00008917743,0.0001871686,0.0002376048,0.000270302,0.00002765177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001245149,"about_ca_system_score_gemma":0.00003176555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006150285,"about_ca_topic_score_gemma":0.00001570609,"domain_scores_codex":[0.9984744,0.00007667238,0.0003453098,0.000385845,0.0004022187,0.0003155267],"domain_scores_gemma":[0.9993336,0.00006501538,0.0001555765,0.0002596261,0.00009366743,0.00009256763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009563731,0.0007570513,0.04143705,0.0004160467,0.001013314,0.00007917166,0.00842752,0.0002386382,0.5973278,0.001559907,0.01384544,0.3339417],"study_design_scores_gemma":[0.008935512,0.001376011,0.2493932,0.0003332335,0.0007982941,0.00008477229,0.00228862,0.003661231,0.6951244,0.00350749,0.03335141,0.0011458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814494,0.01337561,0.00004603081,0.003306713,0.0001718588,0.000700986,0.00007499008,0.0001212416,0.0007531347],"genre_scores_gemma":[0.9967009,0.0003225397,0.001238987,0.0005369207,0.0000530776,0.0001402175,0.0005424697,0.00002823162,0.0004366108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3327959,"threshold_uncertainty_score":0.7973564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008250839773821047,"score_gpt":0.2244436037978967,"score_spread":0.2161927640240756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}