{"id":"W4295087975","doi":"10.3390/molecules27175720","title":"6-Formyl Umbelliferone, a Furanocoumarin from Angelica decursiva L., Inhibits Key Diabetes-Related Enzymes and Advanced Glycation End-Product Formation","year":2022,"lang":"en","type":"article","venue":"Molecules","topic":"Natural Antidiabetic Agents Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; Alberta Children's Hospital; University of Calgary","funders":"National Institute of Biological Resources; Ministry of Education, India; Ministry of Science and ICT, South Korea; National Research Foundation of Korea; Ministry of Environment; National Research Foundation","keywords":"Umbelliferone; Chemistry; Glycation; Biochemistry; Docking (animal); Pharmacology; Coumarin; Enzyme; Advanced glycation end-product; Small molecule; Aldose reductase; Mechanism of action; In vitro; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007725933,0.00026962,0.0002219285,0.0001753582,0.0001000885,0.0001049537,0.0001054675,0.0001571643,0.0006949761],"category_scores_gemma":[0.0000731592,0.0000686382,0.0001990462,0.00011897,0.0000918257,0.0002043075,0.00009818466,0.0003115135,0.0001301881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001560734,"about_ca_system_score_gemma":0.000108549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005281208,"about_ca_topic_score_gemma":0.001012117,"domain_scores_codex":[0.9999635,0.000005851758,0.000002519108,0.000009059207,0.000009010241,0.00001003725],"domain_scores_gemma":[0.9999688,0.00000584012,0.00001388489,0.00000171796,0.000003688217,0.000006106576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002529235,0.00008958373,0.0008880884,0.0003426408,0.00002330375,0.0001744186,0.00002259267,0.0007817612,0.9813679,0.0004091899,0.0001436711,0.01550408],"study_design_scores_gemma":[0.0000560841,0.001470278,0.00577769,0.00003499146,0.00006390223,0.0005489807,0.00002926681,0.003118471,0.9770494,0.0002216835,0.01161506,0.00001409814],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9487473,0.03759198,0.008764822,0.0003524129,0.00007240279,0.00005698824,0.0003849074,0.0001579711,0.003871272],"genre_scores_gemma":[0.9906014,0.006008369,0.001674481,0.00007689249,0.00001241282,0.00001095695,0.0002287105,0.000005187098,0.001381538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006949761,"threshold_uncertainty_score":0.002324998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008250839773821047,"score_gpt":0.2244436037978967,"score_spread":0.2161927640240756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}