{"id":"W4295095543","doi":"10.20517/jtgg.2021.61","title":"The DNA damage response - from cell biology to human disease","year":2022,"lang":"en","type":"article","venue":"Journal of Translational Genetics and Genomics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Hamilton General Hospital","funders":"","keywords":"DNA damage; DNA repair; Biology; Mitochondrial DNA; Genome instability; Genetics; DNA; Carcinogenesis; DNA mismatch repair; Genome; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004743255,0.0004395526,0.0007564476,0.0006458043,0.0004279738,0.002564304,0.0006052096,0.001304612,0.002958148],"category_scores_gemma":[0.0002885055,0.0001739918,0.0002487212,0.0005895155,0.001872637,0.00174683,0.001020777,0.002724365,0.002461386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008566281,"about_ca_system_score_gemma":0.0009082789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003766987,"about_ca_topic_score_gemma":0.000346294,"domain_scores_codex":[0.9996973,0.00006606681,0.00002024773,0.00006639228,0.0001109143,0.00003904192],"domain_scores_gemma":[0.9998322,0.00004083502,0.0000212432,0.00001774028,0.00004316297,0.00004482481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002364575,0.0001528746,0.001280769,0.004826898,0.0000995787,0.001254412,0.0008826316,0.0008395358,0.1347484,0.2075997,0.07101681,0.5770621],"study_design_scores_gemma":[0.00001205182,0.0001346724,0.001487129,0.0006675398,0.00002026666,0.001735589,0.0003032183,0.0001386425,0.01282826,0.03457422,0.9480726,0.00002589981],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003841257,0.9556041,0.005172285,0.01401544,0.003089934,0.000026023,0.000161028,0.0001573916,0.01793257],"genre_scores_gemma":[0.06137981,0.906205,0.003655108,0.006453908,0.002062123,0.00004753264,0.000199023,0.00004612648,0.01995135],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002958148,"threshold_uncertainty_score":0.00989598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009620760530159164,"score_gpt":0.2464438958133656,"score_spread":0.2368231352832065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}