{"id":"W4295096233","doi":"10.2139/ssrn.4205754","title":"Monovalent and Trivalent VSV-Based COVID-19 Vaccines Elicit Potent Neutralizing Antibodies and Immunodominant CD8 <sup>+</sup> T Cells Against Diverse SARS-CoV-2 Variants","year":2022,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Virology; Neutralizing antibody; Antibody; Coronavirus disease 2019 (COVID-19); Immunodominance; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Biology; Cytotoxic T cell; Molecular biology; Chemistry; Epitope; Virus; Medicine; Immunology; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002923888,0.000561827,0.0003845354,0.0002608158,0.0001394447,0.0003558205,0.0002571503,0.0005173713,0.002617721],"category_scores_gemma":[0.0001949789,0.0001762334,0.0002391913,0.0001653988,0.0001903924,0.000338598,0.0003122379,0.001439601,0.000803943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000377172,"about_ca_system_score_gemma":0.0002298054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003955831,"about_ca_topic_score_gemma":0.0007618379,"domain_scores_codex":[0.9996661,0.00004462655,0.00002690656,0.00006472704,0.00005929957,0.0001382377],"domain_scores_gemma":[0.9998736,0.00002839138,0.00002304203,0.00001667471,0.00001587027,0.00004244541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008037344,0.0004246276,0.0007435189,0.00005129307,0.00002467524,0.00004348755,0.00004432843,0.0004332864,0.9917332,0.0001537678,0.0003331965,0.005210947],"study_design_scores_gemma":[0.000800827,0.01632101,0.01987408,0.00003284348,0.0001527627,0.001192919,0.0002981909,0.004810652,0.9452744,0.0004598179,0.01075289,0.00002955909],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963709,0.0003131838,0.001056616,0.00006414386,0.00007547995,0.00005228399,0.0003839599,0.00004948922,0.001634028],"genre_scores_gemma":[0.9937621,0.0002630503,0.001203544,0.0001697647,0.00004566597,0.00006058764,0.001366282,0.00002040513,0.003108687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002617721,"threshold_uncertainty_score":0.008757114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0319765241510522,"score_gpt":0.3147133866247925,"score_spread":0.2827368624737403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}