{"id":"W4295106754","doi":"10.3390/cells11182785","title":"Structure-Based Study to Overcome Cross-Reactivity of Novel Androgen Receptor Inhibitors","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Cancer Society Research Institute; European Synchrotron Radiation Facility; Canadian Cancer Society","keywords":"Androgen receptor; Morpholine; Chemistry; Prostate cancer; Receptor; Androgen; Mutation; Reactivity (psychology); Mutant; Ligand (biochemistry); Biophysics; Stereochemistry; Pharmacology; Biochemistry; Internal medicine; Biology; Medicine; Cancer; Medicinal chemistry; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008352495,0.0002852483,0.0003389531,0.0001213458,0.0001366598,0.0002439547,0.0004399838,0.0002011249,0.001159051],"category_scores_gemma":[0.0000836075,0.0001482416,0.0002684713,0.0001272479,0.0001105491,0.0001564671,0.0001540029,0.0004953471,0.0002294787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003180878,"about_ca_system_score_gemma":0.0002054296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009171771,"about_ca_topic_score_gemma":0.001349019,"domain_scores_codex":[0.9999378,0.000008909991,0.000003280508,0.00001090193,0.00002546207,0.00001354426],"domain_scores_gemma":[0.9999771,0.000003459836,0.000007230198,0.000001770441,0.00000470855,0.000005682548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002897015,0.000355618,0.0005003236,0.0002782886,0.00005803426,0.0002475973,0.00004117353,0.01693333,0.9704167,0.001708075,0.0004735054,0.008697605],"study_design_scores_gemma":[0.000258713,0.002675606,0.002475264,0.00003530316,0.0001301015,0.0004948998,0.00005992101,0.04888862,0.9304784,0.0003305718,0.01414096,0.00003164199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858524,0.0051309,0.005296353,0.0001682088,0.00004044479,0.00007918961,0.0002271017,0.0001071917,0.003098197],"genre_scores_gemma":[0.9911299,0.002431337,0.004332193,0.00008553578,0.000007880191,0.00004211132,0.0004590907,0.00001279408,0.001499123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001159051,"threshold_uncertainty_score":0.003877401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02944005469691364,"score_gpt":0.3348691479952535,"score_spread":0.3054290932983399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}