{"id":"W4295106754","doi":"10.3390/cells11182785","title":"Structure-Based Study to Overcome Cross-Reactivity of Novel Androgen Receptor Inhibitors","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Cancer Society Research Institute; European Synchrotron Radiation Facility; Canadian Cancer Society","keywords":"Androgen receptor; Morpholine; Chemistry; Prostate cancer; Receptor; Androgen; Mutation; Reactivity (psychology); Mutant; Ligand (biochemistry); Biophysics; Stereochemistry; Pharmacology; Biochemistry; Internal medicine; Biology; Medicine; Cancer; Medicinal chemistry; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001983042,0.0001111426,0.0002421946,0.0001288053,0.0001138923,0.00001214273,0.0000997801,0.00002262759,0.0009979521],"category_scores_gemma":[0.00001971475,0.00009079005,0.00006956548,0.0003396567,0.0000405771,0.00003423618,0.0001297251,0.0001923581,0.00001018767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000261585,"about_ca_system_score_gemma":0.0002123754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001543684,"about_ca_topic_score_gemma":0.000008531688,"domain_scores_codex":[0.9988288,0.00004615909,0.0001686271,0.0002559782,0.000485247,0.0002152015],"domain_scores_gemma":[0.9993864,0.00005377324,0.00005339926,0.0002924343,0.00007397297,0.000140046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001277933,0.002654481,0.1799383,0.00005845832,0.00008243392,0.00002623779,0.001127365,0.0003293126,0.8126096,0.000002474999,0.001004889,0.0008884943],"study_design_scores_gemma":[0.005965095,0.002358029,0.03845599,0.00001470451,0.00004146507,0.000002107951,0.0005111944,0.00003034605,0.9466577,0.000005506628,0.005838796,0.000119069],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977548,0.00008111969,0.000009843326,0.0001845583,0.0003192902,0.001106,0.0003129546,0.00002254819,0.0002089301],"genre_scores_gemma":[0.9980937,0.000001206136,0.0001485846,0.0001039105,0.0000716258,0.00004717403,0.00004624033,0.00001982469,0.001467793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1414823,"threshold_uncertainty_score":0.9999152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02944005469691364,"score_gpt":0.3348691479952535,"score_spread":0.3054290932983399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}