{"id":"W4295154783","doi":"10.1002/ehf2.14120","title":"Insulin-Like Growth Factor Binding Protein 7 (IGFBP7), a Link Between Heart Failure and Senescence","year":2022,"lang":"en","type":"article","venue":"ESC Heart Failure","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Surgical Specialties (Canada)","funders":"Netherlands Heart Institute; ICIN Netherlands Heart Institute; European Research Council; Fondation Leducq; National Institute for Health and Care Research","keywords":"Medicine; Heart failure; Biomarker; Internal medicine; Renal function; Proportional hazards model; Ejection fraction; Cohort; Cardiology; Diabetes mellitus; Endocrinology; Prospective cohort study","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005927946,0.0006383974,0.001083827,0.0005658877,0.0009700148,0.0001276145,0.0003135315,0.0003711951,0.0005595586],"category_scores_gemma":[0.0002775236,0.0006356902,0.000308244,0.001227706,0.0002071923,0.0004404951,0.000539501,0.001988993,0.0002370476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002663883,"about_ca_system_score_gemma":0.0004252706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002030901,"about_ca_topic_score_gemma":0.00001782827,"domain_scores_codex":[0.9954485,0.0003409513,0.0008182548,0.001115848,0.001162803,0.001113686],"domain_scores_gemma":[0.9978405,0.0001778471,0.0001893091,0.0007392882,0.0002068139,0.0008462953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003089102,0.0002817316,0.6092882,0.0006539726,0.0002942705,0.0002036668,0.001766639,0.000001722934,0.3247646,0.0003228816,0.0599342,0.002179235],"study_design_scores_gemma":[0.004370738,0.002212758,0.1782666,0.0003365685,0.0002027523,0.0005541916,0.001547412,0.00005504085,0.03795459,0.0001827352,0.7729734,0.001343253],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9493751,0.0004605127,0.00006255246,0.04732899,0.000284256,0.001777078,0.0002261864,0.0003965738,0.00008875784],"genre_scores_gemma":[0.9901431,0.000019822,0.005963691,0.001482247,0.000977524,0.0002345187,0.0002185318,0.0001412214,0.0008193135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7130392,"threshold_uncertainty_score":0.9996094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01725727110946108,"score_gpt":0.2445124143262782,"score_spread":0.2272551432168172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}