{"id":"W4295182896","doi":"10.1038/s41419-022-05128-6","title":"Deubiquitinase OTUD5 modulates mTORC1 signaling to promote bladder cancer progression","year":2022,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"National Natural Science Foundation of China","keywords":"PI3K/AKT/mTOR pathway; Deubiquitinating enzyme; mTORC1; Cancer research; Ubiquitin ligase; Regulator; Cancer; Biology; Signal transduction; Bladder cancer; Tumor progression; RPTOR; Ubiquitin; Cell biology; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001152701,0.0001597477,0.0001002304,0.00003715354,0.0003284925,0.00003694586,0.0001296412,0.00003643439,0.000233656],"category_scores_gemma":[0.00003435118,0.0001520581,0.00006156231,0.00007054921,0.00002294221,0.000003824034,0.0003060475,0.00008243291,0.000006550672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001548459,"about_ca_system_score_gemma":0.0001478992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001427934,"about_ca_topic_score_gemma":0.000001519531,"domain_scores_codex":[0.9989389,0.00006079593,0.0001254178,0.0004246809,0.0001618201,0.0002883676],"domain_scores_gemma":[0.9990838,0.0000045082,0.00004571623,0.0002229466,0.00003832517,0.0006047311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007213927,0.0003102597,0.01381239,0.0001577082,0.00003106563,0.00008229682,0.0002522446,0.0009930739,0.9695877,0.00009212377,0.003059863,0.01089984],"study_design_scores_gemma":[0.001264325,0.0008191356,0.002358005,0.00004957018,0.000100985,0.000008604925,0.000165894,0.0008062843,0.8686984,0.0006631784,0.1243633,0.0007023845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99273,0.005567763,0.0001526104,0.0002149643,0.00007974283,0.000497565,0.000166101,0.00002561846,0.0005656769],"genre_scores_gemma":[0.9963627,0.00007016019,0.0003613957,0.001296079,0.0002000005,0.0004858779,0.0001608769,0.000027546,0.001035333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1213034,"threshold_uncertainty_score":0.620075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01275594162979327,"score_gpt":0.261907678777783,"score_spread":0.2491517371479897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}