{"id":"W4295213395","doi":"10.3390/pharmaceutics14091910","title":"The TH1902 Docetaxel Peptide-Drug Conjugate Inhibits Xenografts Growth of Human SORT1-Positive Ovarian and Triple-Negative Breast Cancer Stem-like Cells","year":2022,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; Theratechnologies (Canada)","funders":"Mitacs; Québec Consortium for Drug Discovery; Fondation du cancer du sein du Québec; U.S. Department of Veterans Affairs","keywords":"Docetaxel; Ovarian cancer; Cancer research; Triple-negative breast cancer; SOX2; Cancer stem cell; Stem cell; Homeobox protein NANOG; Pharmacology; Internal medicine; Medicine; Biology; Breast cancer; Cancer; Cell biology; Induced pluripotent stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009254513,0.000295154,0.0002068045,0.0001660309,0.00008216749,0.0002033058,0.0001227661,0.0001583388,0.001237716],"category_scores_gemma":[0.00005123683,0.00009710559,0.0001368487,0.0001286693,0.0001003076,0.00008879596,0.00005770071,0.0003831402,0.0002715199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003171068,"about_ca_system_score_gemma":0.0002775061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009934939,"about_ca_topic_score_gemma":0.001775142,"domain_scores_codex":[0.999951,0.000007330794,0.000004085567,0.000008836902,0.00001544072,0.00001326929],"domain_scores_gemma":[0.9999638,0.000006842869,0.000008258437,0.000003612747,0.000003495852,0.00001410123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006046875,0.0002746244,0.0003099702,0.00005740371,0.00001558739,0.00005163692,0.00002082835,0.0002296002,0.9927844,0.0001117461,0.0003810743,0.005158536],"study_design_scores_gemma":[0.0002158796,0.00347983,0.003539422,0.000005267126,0.00003485844,0.0003353386,0.00001890538,0.001777615,0.9869466,0.00002051815,0.003620769,0.000005065075],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967594,0.0007119642,0.0005201985,0.00006623745,0.00002391597,0.00004355108,0.0003795442,0.00006971726,0.001425552],"genre_scores_gemma":[0.9956933,0.0006664029,0.0007332541,0.00003836857,0.000008584962,0.000034475,0.0008512749,0.00001381599,0.001960725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001237716,"threshold_uncertainty_score":0.004140615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03065137511125202,"score_gpt":0.3177304778588931,"score_spread":0.287079102747641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}