{"id":"W4295213395","doi":"10.3390/pharmaceutics14091910","title":"The TH1902 Docetaxel Peptide-Drug Conjugate Inhibits Xenografts Growth of Human SORT1-Positive Ovarian and Triple-Negative Breast Cancer Stem-like Cells","year":2022,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; Theratechnologies (Canada)","funders":"Mitacs; Québec Consortium for Drug Discovery; Fondation du cancer du sein du Québec; U.S. Department of Veterans Affairs","keywords":"Docetaxel; Ovarian cancer; Cancer research; Triple-negative breast cancer; SOX2; Cancer stem cell; Stem cell; Homeobox protein NANOG; Pharmacology; Internal medicine; Medicine; Biology; Breast cancer; Cancer; Cell biology; Induced pluripotent stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005627985,0.0002828834,0.0004796126,0.0001141528,0.000691421,0.00004070744,0.0001776651,0.00003543837,0.0003278824],"category_scores_gemma":[0.000007855232,0.0002227287,0.0001579529,0.0004307539,0.0004028202,0.0000932988,0.0002746443,0.0005898104,0.000004285254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001870118,"about_ca_system_score_gemma":0.0002405554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001053194,"about_ca_topic_score_gemma":0.0002000033,"domain_scores_codex":[0.9978958,0.0002409022,0.0004739308,0.0003882414,0.0005516731,0.0004493912],"domain_scores_gemma":[0.9986984,0.0001847971,0.0003334267,0.000258055,0.0002689454,0.0002564006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009346632,0.002566647,0.03434625,0.002224813,0.005919944,0.0004049044,0.03763228,0.0002891047,0.7901415,0.003609261,0.06214928,0.05136942],"study_design_scores_gemma":[0.01336672,0.0004785073,0.009108406,0.0002034401,0.002311624,0.0002321644,0.00449064,0.0005594199,0.9348716,0.0003102455,0.03340453,0.0006627422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790999,0.006588179,0.00002937873,0.00457201,0.001581314,0.002052134,0.002549085,0.00007834099,0.003449703],"genre_scores_gemma":[0.9920325,0.002744689,0.00006219859,0.001302824,0.0002278453,0.0001326879,0.0000233224,0.00005191902,0.003422042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1447301,"threshold_uncertainty_score":0.9082613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03065137511125202,"score_gpt":0.3177304778588931,"score_spread":0.287079102747641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}