{"id":"W4295255159","doi":"10.1016/j.jaad.2022.06.558","title":"32923 A multicenter, double-blind, randomized, placebo-controlled, phase IIb dose-finding study to evaluate efficacy and safety of spesolimab in patients with moderate-to-severe palmoplantar pustulosis","year":2022,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Autoimmune Bullous Skin Diseases","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Innovaderm (Canada); Institute of Infection and Immunity","funders":"","keywords":"Palmoplantar pustulosis; Medicine; Placebo; Double blind; Multicenter study; Randomized controlled trial; Dermatology; Internal medicine; Psoriasis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002266084,0.001973404,0.003448068,0.0005181251,0.0006145287,0.0009342119,0.0007236945,0.001970398,0.009103114],"category_scores_gemma":[0.001436424,0.0007428359,0.001671851,0.0004499989,0.001005861,0.000808429,0.0003323821,0.002945957,0.001598075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004897115,"about_ca_system_score_gemma":0.001340105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007237366,"about_ca_topic_score_gemma":0.001521679,"domain_scores_codex":[0.9992193,0.0004543425,0.00005233469,0.0001079006,0.00005331095,0.0001128332],"domain_scores_gemma":[0.9991659,0.0002039531,0.0001300583,0.00006042517,0.00007118257,0.0003684573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9493269,0.01522882,0.0009935288,0.0007261761,0.001185531,0.0001022065,0.00007443674,0.0003848288,0.01085743,0.0001682349,0.001879289,0.01907261],"study_design_scores_gemma":[0.9377576,0.05982637,0.001229638,0.00001355015,0.0001853983,0.00003127255,0.000009836215,0.0001744386,0.0002986024,0.00005964268,0.0004027456,0.00001103239],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779855,0.005491903,0.001313453,0.000980959,0.0005766926,0.007826184,0.002030771,0.0002277497,0.003566729],"genre_scores_gemma":[0.9790055,0.002439334,0.003222224,0.002343919,0.0005373185,0.005961774,0.002412485,0.00004880118,0.004028567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009103114,"threshold_uncertainty_score":0.03045297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02055645827179397,"score_gpt":0.3321643663996288,"score_spread":0.3116079081278348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}