{"id":"W4295259512","doi":"10.1016/j.jaad.2022.06.237","title":"33180 Efficacy and safety of the oral JAK3/TEC inhibitor ritlecitinib in adolescents with alopecia areata: Results from the ALLEGRO Phase 2b/3 randomized, double-blind, placebo-controlled trial","year":2022,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Probity Medical Research","funders":"","keywords":"Medicine; Alopecia areata; Double blind; Placebo; Dermatology; TEC; Randomized controlled trial; Internal medicine; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007426894,0.0008229351,0.002083899,0.0002116851,0.0003087034,0.0006786947,0.0004304118,0.001429575,0.004558303],"category_scores_gemma":[0.0006789432,0.000364072,0.001653072,0.0002193163,0.0005523607,0.0006730539,0.0001720086,0.002554433,0.0009480389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004291794,"about_ca_system_score_gemma":0.0005326954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004959418,"about_ca_topic_score_gemma":0.001344298,"domain_scores_codex":[0.9997209,0.0001170262,0.0000214591,0.00005480494,0.00003035942,0.00005542897],"domain_scores_gemma":[0.9996455,0.0001276719,0.00008795461,0.00001811145,0.00002623133,0.00009461365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8699069,0.005943019,0.002878072,0.003169299,0.002790028,0.0001808726,0.00009325246,0.0008012012,0.01136557,0.0002855123,0.00348395,0.09910236],"study_design_scores_gemma":[0.9205962,0.06507791,0.008424862,0.0001609477,0.001371084,0.0001913203,0.00003773509,0.0006063237,0.001241068,0.0001689479,0.0020926,0.00003084234],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9666758,0.02631154,0.0005316635,0.0008290765,0.000357226,0.001097966,0.001109738,0.0001818832,0.002905059],"genre_scores_gemma":[0.9891217,0.00574073,0.0007434205,0.0009455062,0.0002445015,0.0007778404,0.0008594727,0.00001845237,0.001548282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004558303,"threshold_uncertainty_score":0.01524901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03011554872657412,"score_gpt":0.3270124437933456,"score_spread":0.2968968950667715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}