{"id":"W4295259512","doi":"10.1016/j.jaad.2022.06.237","title":"33180 Efficacy and safety of the oral JAK3/TEC inhibitor ritlecitinib in adolescents with alopecia areata: Results from the ALLEGRO Phase 2b/3 randomized, double-blind, placebo-controlled trial","year":2022,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Probity Medical Research","funders":"","keywords":"Medicine; Alopecia areata; Double blind; Placebo; Dermatology; TEC; Randomized controlled trial; Internal medicine; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001042966,0.0002074995,0.001770659,0.0001688343,0.0001838583,0.00001066701,0.0005140795,0.00006601083,0.00003324903],"category_scores_gemma":[0.0007716498,0.00009332209,0.0004511135,0.0004229584,0.0008559697,0.00006914275,0.0002057481,0.001528362,5.325614e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006803733,"about_ca_system_score_gemma":0.0002452229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000226862,"about_ca_topic_score_gemma":0.00002943871,"domain_scores_codex":[0.9960016,0.001383391,0.001637559,0.0001955104,0.0005543184,0.0002276097],"domain_scores_gemma":[0.9956114,0.001324995,0.002636205,0.0002516156,0.00009246027,0.00008328397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9921338,0.0007063214,0.0008465325,0.000009942629,0.0005181627,0.0000251836,0.0006097569,0.000167662,0.002670577,0.00003254217,0.001727197,0.0005523126],"study_design_scores_gemma":[0.9864411,0.0006792193,0.001588352,0.000435223,0.0007209324,0.001447762,0.0008054333,0.0001674171,0.003442726,0.00003671554,0.004138843,0.00009621534],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9715105,0.0003408894,0.00002511502,0.02547844,0.00033113,0.002097098,0.00009060519,0.00000453864,0.0001217322],"genre_scores_gemma":[0.9982613,0.0001230478,0.00006598369,0.00118071,0.0002775884,0.00004087739,0.000003633942,0.00001922807,0.00002767307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0267508,"threshold_uncertainty_score":0.6640058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03011554872657412,"score_gpt":0.3270124437933456,"score_spread":0.2968968950667715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}