{"id":"W4295260678","doi":"10.1136/jnnp-2022-ehdn.260","title":"J10 Analysis of integrated safety data from pridopidine clinical trials demonstrates a favorable safety and tolerability profile at the clinically relevant dose of 45 mg bid","year":2022,"lang":"en","type":"article","venue":"","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Tolerability; Placebo; Medicine; Adverse effect; QT interval; Clinical trial; Anesthesia; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.01314201,0.0001952158,0.001156363,0.00004025668,0.000164022,0.00001131248,0.000649323,0.0001878504,0.003989588],"category_scores_gemma":[0.005207179,0.0001142414,0.0003812234,0.0004246372,0.000298926,0.000006181101,0.00170093,0.0003085639,0.000002024615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002886746,"about_ca_system_score_gemma":0.0002298391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002623737,"about_ca_topic_score_gemma":0.000166381,"domain_scores_codex":[0.9937994,0.002989185,0.001970989,0.0007669223,0.0002500119,0.0002234317],"domain_scores_gemma":[0.9957663,0.002233869,0.0007358011,0.0009990784,0.0001259361,0.0001389728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009017848,0.0007074091,0.02228504,0.00002022627,0.002147782,0.000001937972,0.00001973828,0.0003151099,0.9501849,0.0000573406,0.002573106,0.01266959],"study_design_scores_gemma":[0.01080795,0.008279698,0.08861395,0.0000437313,0.007179916,0.000006866152,0.001019733,0.08789674,0.6858263,0.0006584459,0.10859,0.001076681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906528,0.0006273541,0.00170059,0.0003824557,0.0001869556,0.0006966104,0.005438521,0.00001175278,0.0003029519],"genre_scores_gemma":[0.9917207,0.00162639,0.001549965,0.0002771303,0.0000627994,0.00002851481,0.004428736,0.00001106088,0.0002946771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2643586,"threshold_uncertainty_score":0.9969209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1042145365724796,"score_gpt":0.4104804597302332,"score_spread":0.3062659231577536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}