{"id":"W4295260678","doi":"10.1136/jnnp-2022-ehdn.260","title":"J10 Analysis of integrated safety data from pridopidine clinical trials demonstrates a favorable safety and tolerability profile at the clinically relevant dose of 45 mg bid","year":2022,"lang":"en","type":"article","venue":"","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Tolerability; Placebo; Medicine; Adverse effect; QT interval; Clinical trial; Anesthesia; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01305836,0.0005190401,0.002024391,0.0008649716,0.0001585023,0.00134984,0.0003768156,0.0003570334,0.005839794],"category_scores_gemma":[0.01164278,0.0002860973,0.002991197,0.00123995,0.0002988891,0.0005611748,0.0005252516,0.0006573795,0.0007447323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004213057,"about_ca_system_score_gemma":0.001201133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006873105,"about_ca_topic_score_gemma":0.001953506,"domain_scores_codex":[0.9926695,0.003801313,0.0009059728,0.0009364866,0.001342731,0.0003440063],"domain_scores_gemma":[0.9806916,0.01158139,0.004320677,0.001236953,0.001798303,0.000371224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.1619229,0.001697779,0.3608138,0.0167297,0.07662618,0.0007126796,0.0005006601,0.007098863,0.06677942,0.001210726,0.0181008,0.2878066],"study_design_scores_gemma":[0.0143484,0.04862677,0.8263378,0.0007724717,0.032517,0.002050184,0.0002476091,0.01026859,0.02045239,0.0009730348,0.0432356,0.0001700509],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8862548,0.03596694,0.02215724,0.0008946126,0.0001801301,0.002773165,0.03588929,0.0009566859,0.01492711],"genre_scores_gemma":[0.9700801,0.003471008,0.006464847,0.0005204583,0.0001099607,0.0007168279,0.01630494,0.0001677088,0.002164192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01305836,"threshold_uncertainty_score":0.06906003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1042145365724796,"score_gpt":0.4104804597302332,"score_spread":0.3062659231577536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}