{"id":"W4295260781","doi":"10.1136/jnnp-2022-ehdn.24","title":"A24 Mutant huntingtin impairs musculoskeletal and brain growth via disturbing testosterone biosynthesis in male huntington disease animals","year":2022,"lang":"en","type":"article","venue":"","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"","keywords":"Internal medicine; Endocrinology; Huntingtin; Testosterone (patch); Biology; Huntingtin Protein; Hormone; Atrophy; Huntington's disease; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001629672,0.0004468858,0.000317385,0.0009501722,0.0002274963,0.0003334447,0.0002819889,0.0004222391,0.002899217],"category_scores_gemma":[0.000118089,0.0002756689,0.0004042249,0.0002084897,0.0004251508,0.0002103882,0.0002451359,0.0006770807,0.0005483768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002894342,"about_ca_system_score_gemma":0.0001891876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001805317,"about_ca_topic_score_gemma":0.00281831,"domain_scores_codex":[0.9997974,0.00002557193,0.00002255766,0.00005476201,0.000057419,0.00004227957],"domain_scores_gemma":[0.9996347,0.00002520068,0.0001547787,0.0000269558,0.00002176582,0.0001364368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003721637,0.0001084718,0.0008341229,0.00002610911,0.00001601267,0.0001872014,0.00003783505,0.00003431568,0.9970492,0.00006368571,0.00006547767,0.001205451],"study_design_scores_gemma":[0.00013391,0.003153298,0.132108,0.00003847806,0.0001205991,0.00154603,0.0003386344,0.001263455,0.8568853,0.0002397574,0.004125881,0.00004660297],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997146,0.0004764124,0.0007761696,0.00008441572,0.00003006226,0.00001398137,0.0007261155,0.00009255987,0.0006543974],"genre_scores_gemma":[0.9903307,0.0005338915,0.0008918514,0.0001229123,0.00002213689,0.00005862883,0.0008451566,0.0000800259,0.007114666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002899217,"threshold_uncertainty_score":0.009698868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01325018475485732,"score_gpt":0.2424801370424915,"score_spread":0.2292299522876342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}