{"id":"W4295277024","doi":"10.1016/j.jbc.2022.102473","title":"A defect in cell wall recycling confers antibiotic resistance and sensitivity in Staphylococcus aureus","year":2022,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Autolysis (biology); Lipid II; Microbiology; Peptidoglycan; Bacitracin; Antibiotics; Biology; Staphylococcus aureus; Tunicamycin; Vancomycin; Bacterial cell structure; Cell wall; Bacteria; Biochemistry; Enzyme; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001091361,0.0001771149,0.0005948013,0.00009589279,0.00006142184,0.00001388635,0.00009303922,0.0001360403,0.00005858729],"category_scores_gemma":[0.0004319118,0.0001463503,0.0001716272,0.0003121974,0.0001697692,0.00003719081,0.0001079335,0.001128188,6.282188e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003273806,"about_ca_system_score_gemma":0.0001604428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001408672,"about_ca_topic_score_gemma":0.00002359958,"domain_scores_codex":[0.9983734,0.0001512165,0.0006138551,0.0002873796,0.0002469705,0.0003271397],"domain_scores_gemma":[0.9989536,0.0003134272,0.0003608398,0.0001580942,0.00007627351,0.0001376969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001350708,0.0002708325,0.1883325,0.0001357957,0.00001629302,0.003069941,0.00007048962,0.00005848536,0.8062536,0.000003214422,0.0003233854,0.0001146755],"study_design_scores_gemma":[0.01011642,0.001060828,0.456239,0.001079762,0.00009991421,0.0009933733,0.00242687,0.0001566213,0.5140728,0.0003772379,0.01253067,0.0008464694],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958889,0.001468109,0.00001552755,0.0008282582,0.00004662887,0.0001585614,0.00001350546,0.000009902998,0.001570561],"genre_scores_gemma":[0.9983247,0.0003375803,0.0006323632,0.0005218632,0.00004688459,0.000001803065,0.000004251081,0.00001151365,0.0001190276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2921808,"threshold_uncertainty_score":0.5967993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01992250411766098,"score_gpt":0.2616497751846705,"score_spread":0.2417272710670095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}