{"id":"W4295279851","doi":"10.1021/acsnano.2c05010","title":"A Photoresponsive Intramolecular Triplex Motif That Enables Rapid and Reversible Control of Aptamer Binding Activity","year":2022,"lang":"en","type":"article","venue":"ACS Nano","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Chemistry; National Institute of General Medical Sciences; NIH Office of the Director; Stanford University; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health","keywords":"Photoswitch; Photoisomerization; Azobenzene; Aptamer; Intramolecular force; DNA; Chemistry; Molecular switch; Isomerization; Biophysics; Materials science; Photochemistry; Molecule; Stereochemistry; Biochemistry; Catalysis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001212796,0.0002507386,0.0001656567,0.0001078785,0.0001118473,0.0002143283,0.0002206972,0.0002946842,0.0008934014],"category_scores_gemma":[0.00015778,0.0001437688,0.0001539773,0.0001127855,0.0001951893,0.0002062405,0.0001541685,0.000580615,0.0002194234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002372536,"about_ca_system_score_gemma":0.0001854327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003227345,"about_ca_topic_score_gemma":0.0006394162,"domain_scores_codex":[0.9999115,0.000008444749,0.000005746781,0.00003272059,0.00002894621,0.00001258886],"domain_scores_gemma":[0.9999331,0.0000130129,0.00002357901,0.000007184434,0.000007887156,0.00001522126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001069895,0.000009349194,0.00004255733,0.0000166583,0.000002120394,0.00001438268,0.00000586075,0.0002154206,0.9979506,0.0001568643,0.00001579987,0.001559663],"study_design_scores_gemma":[0.00000583702,0.0001643887,0.0003053159,0.000001626292,0.000004586482,0.0001112973,0.000003635705,0.00141448,0.9965616,0.00003653339,0.001385975,0.000004674574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9367118,0.0009452317,0.0587975,0.0001255005,0.00005035669,0.0001025539,0.0002052041,0.0003346069,0.00272728],"genre_scores_gemma":[0.9703611,0.0003870779,0.02611452,0.00006073036,0.00001165855,0.00005752132,0.0001933813,0.00003557446,0.002778368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008934014,"threshold_uncertainty_score":0.002988756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009764873507165374,"score_gpt":0.2365894356950275,"score_spread":0.2268245621878621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}