{"id":"W4295346540","doi":"10.1136/bmj-2022-071375","title":"Efficacy and safety of extended duration to perioperative thromboprophylaxis with low molecular weight heparin on disease-free survival after surgical resection of colorectal cancer (PERIOP-01): multicentre, open label, randomised controlled trial","year":2022,"lang":"en","type":"article","venue":"BMJ","topic":"Venous Thromboembolism Diagnosis and Management","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Humber River Regional Hospital; Essar Steel Algoma (Canada); Kingston Health Sciences Centre; University of Ottawa; McGill University; Science North; Institut du Savoir Montfort; London Health Sciences Centre; Queensway-Carleton Hospital; North York General Hospital; Sault Area Hospital; Jewish General Hospital; Sunnybrook Health Science Centre; Montfort Hospital; Ottawa Hospital; Health Sciences Centre; St Joseph's Health Centre","funders":"Canadian Institutes of Health Research; Canada Foundation for Innovation","keywords":"Medicine; Colorectal cancer; Perioperative; Low molecular weight heparin; Randomized controlled trial; Open label; Surgery; Heparin; Overall survival; Oncology; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003402309,0.001389551,0.002749197,0.0003497327,0.0004100139,0.001134937,0.0009603936,0.002287802,0.004580047],"category_scores_gemma":[0.004894949,0.0005849746,0.002274254,0.0004461478,0.00113693,0.0008982837,0.0004376966,0.001932657,0.0004746124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001242398,"about_ca_system_score_gemma":0.002014279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002551172,"about_ca_topic_score_gemma":0.004808981,"domain_scores_codex":[0.9980466,0.001228217,0.0001601131,0.0002588447,0.0001322258,0.0001740106],"domain_scores_gemma":[0.9969738,0.001104444,0.0009913649,0.0001558314,0.0001833316,0.000591237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9919511,0.001677806,0.0003563138,0.0006287993,0.0004633997,0.00001184884,0.00001870878,0.00009591276,0.000450873,0.00002203975,0.0001492625,0.004173843],"study_design_scores_gemma":[0.9531658,0.0444352,0.001441493,0.00006097944,0.0003818675,0.00001373858,0.000008327414,0.000161313,0.0001141606,0.00002909159,0.0001804383,0.00000756062],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826016,0.007573907,0.0006004853,0.0005463819,0.0005462113,0.005985483,0.0009025155,0.00006035192,0.001183031],"genre_scores_gemma":[0.9833258,0.003326702,0.001700913,0.0007327368,0.0006353773,0.008103958,0.0006863783,0.00001090916,0.00147719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004580047,"threshold_uncertainty_score":0.01799333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01315565156482324,"score_gpt":0.3057929480136046,"score_spread":0.2926372964487813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}