{"id":"W4295346816","doi":"10.1016/j.cryobiol.2022.09.002","title":"Multiple cryoprotectant toxicity model for vitrification solution optimization","year":2022,"lang":"en","type":"article","venue":"Cryobiology","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institutes of Health; National Science Foundation","keywords":"Vitrification; Cryoprotectant; Toxicity; Molality; Formamide; Dimethyl sulfoxide; Chemistry; Glycerol; Ethylene glycol; Cryopreservation; Chromatography; Biochemistry; Organic chemistry; Biology; Aqueous solution; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002557293,0.0007187017,0.0004883633,0.0003889739,0.0002757582,0.0005141135,0.0006354658,0.0005627153,0.00214419],"category_scores_gemma":[0.0004253366,0.0001921238,0.0007486488,0.0003867762,0.000196609,0.0004823122,0.0004299761,0.0005837962,0.0002190346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007099687,"about_ca_system_score_gemma":0.000968445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004137546,"about_ca_topic_score_gemma":0.003907122,"domain_scores_codex":[0.9998708,0.00001667828,0.000004883529,0.00003442724,0.00004643316,0.00002678334],"domain_scores_gemma":[0.9998726,0.00003983484,0.00002049973,0.00001038976,0.00004662263,0.00001011944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001098119,0.0001266162,0.001437668,0.000189974,0.00004181426,0.00007979648,0.00002207621,0.9360526,0.0411829,0.002826477,0.0008162585,0.01711397],"study_design_scores_gemma":[0.00001215904,0.0002276403,0.0008845796,0.00001236398,0.00004201275,0.0000275622,0.00002293401,0.9783998,0.01793954,0.0009727072,0.001448365,0.00001035696],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.67834,0.00218922,0.2952559,0.0005820806,0.0001218664,0.0002273212,0.001024937,0.0004627008,0.02179605],"genre_scores_gemma":[0.9493591,0.0009164033,0.04024158,0.0000999086,0.00001209269,0.000248293,0.0007139322,0.00009212811,0.008316607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004137546,"threshold_uncertainty_score":0.008226931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04684404715173467,"score_gpt":0.2864425770940212,"score_spread":0.2395985299422865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}