{"id":"W4295412535","doi":"10.1038/s12276-022-00848-3","title":"Activating SIRT3 in peritoneal mesothelial cells alleviates postsurgical peritoneal adhesion formation by decreasing oxidative stress and inhibiting the NLRP3 inflammasome","year":2022,"lang":"en","type":"article","venue":"Experimental & Molecular Medicine","topic":"Intestinal and Peritoneal Adhesions","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"National Natural Science Foundation of China","keywords":"Inflammasome; Mesothelial Cell; Oxidative stress; Adhesion; SIRT3; Chemistry; Cancer research; Medicine; Cell biology; Immunology; Inflammation; Pathology; Biology; Biochemistry; Acetylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004829526,0.0003426617,0.0004660463,0.0001587938,0.0006539465,0.00003402189,0.0001563488,0.00008004084,0.0003981638],"category_scores_gemma":[0.0001674317,0.000251691,0.00009203762,0.0003264101,0.0003056489,0.0001886201,0.0003321427,0.0007208513,0.000004179424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002952773,"about_ca_system_score_gemma":0.00006706807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006771889,"about_ca_topic_score_gemma":0.00000735168,"domain_scores_codex":[0.9972996,0.000364424,0.0005995221,0.0004440552,0.0008333265,0.00045912],"domain_scores_gemma":[0.9990428,0.0002664891,0.0002007202,0.000200855,0.0000639831,0.0002251706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005328924,0.0002912561,0.0005623993,0.00005368443,0.00002301196,0.0003930293,0.008545872,0.00001497384,0.9882786,0.0002085125,0.0001438713,0.0009518458],"study_design_scores_gemma":[0.002690464,0.001733499,0.001013379,0.0005126896,0.00003434046,0.0007938822,0.03242975,0.001495681,0.957802,0.00003861712,0.0011861,0.0002696272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905755,0.003362462,0.0000443633,0.004067394,0.0001497812,0.0007367796,0.0000302977,0.00005756263,0.0009758712],"genre_scores_gemma":[0.9973605,0.00004882026,0.0005226621,0.00130629,0.0002420235,0.000161455,0.0002266062,0.0000473515,0.00008426996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03047668,"threshold_uncertainty_score":0.9999935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01190454412983632,"score_gpt":0.2786888752989552,"score_spread":0.2667843311691189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}