{"id":"W4295423187","doi":"10.1172/jci159579","title":"Immune dysfunction signatures predict outcomes and define checkpoint blockade–unresponsive microenvironments in acute myeloid leukemia","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; Huntsman Cancer Foundation; Genentech; National Institutes of Health; Technische Universität Dresden; Fonds National de la Recherche Luxembourg; Johns Hopkins University; American Society for Transplantation and Cellular Therapy; Qatar National Research Fund; American Society of Clinical Oncology; Huntsman Cancer Institute; National Heart, Lung, and Blood Institute; John and Lucille Van Geest Foundation; Gabrielle's Angel Foundation for Cancer Research; American Association for Cancer Research; St. Baldrick's Foundation; Trent University; Ladies Leukemia League; Leukemia and Lymphoma Society; Stand Up To Cancer; Entertainment Industry Foundation; U.S. Department of Defense; Rally Foundation; Children's Hospital of Philadelphia; Nottingham Trent University; Conquer Cancer Foundation","keywords":"Myeloid leukemia; Medicine; Immune checkpoint; Blockade; Immunotherapy; Oncology; CD8; Immune system; Leukemia; Effector; Internal medicine; Immunology; Cancer research; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004674896,0.0002305762,0.0003369936,0.0006144664,0.0001467033,0.0005147838,0.0001819668,0.0002368206,0.00103022],"category_scores_gemma":[0.0006314826,0.000105834,0.0001920692,0.0005387474,0.0002339792,0.0001852613,0.0003850199,0.000392975,0.0001943432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002787872,"about_ca_system_score_gemma":0.0001802442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003597598,"about_ca_topic_score_gemma":0.0007216319,"domain_scores_codex":[0.9998205,0.00003688918,0.00001746036,0.00004870073,0.00003683069,0.00003966306],"domain_scores_gemma":[0.9996257,0.00007644437,0.0001869219,0.000020969,0.00004050246,0.00004940178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002072389,0.0001715168,0.9253362,0.0001225062,0.0001413179,0.0001004281,0.0001186737,0.001543696,0.03802218,0.0001556091,0.0008206369,0.03139485],"study_design_scores_gemma":[0.000052475,0.0004517517,0.9837357,0.00002343821,0.0001146218,0.0002967874,0.0001817401,0.004501995,0.008035829,0.0006688553,0.001924825,0.00001186823],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977399,0.0006242258,0.0005342602,0.00007272909,0.000005453329,0.00001743339,0.0006322056,0.00001247012,0.0003613934],"genre_scores_gemma":[0.9979978,0.0001996668,0.0006446978,0.0000905173,0.00001184729,0.00002886209,0.0008206624,0.000005864606,0.0002000074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00103022,"threshold_uncertainty_score":0.0034464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03017100444525617,"score_gpt":0.3197234006004307,"score_spread":0.2895523961551745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}