{"id":"W4295423187","doi":"10.1172/jci159579","title":"Immune dysfunction signatures predict outcomes and define checkpoint blockade–unresponsive microenvironments in acute myeloid leukemia","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; Huntsman Cancer Foundation; Genentech; National Institutes of Health; Technische Universität Dresden; Fonds National de la Recherche Luxembourg; Johns Hopkins University; American Society for Transplantation and Cellular Therapy; Qatar National Research Fund; American Society of Clinical Oncology; Huntsman Cancer Institute; National Heart, Lung, and Blood Institute; John and Lucille Van Geest Foundation; Gabrielle's Angel Foundation for Cancer Research; American Association for Cancer Research; St. Baldrick's Foundation; Trent University; Ladies Leukemia League; Leukemia and Lymphoma Society; Stand Up To Cancer; Entertainment Industry Foundation; U.S. Department of Defense; Rally Foundation; Children's Hospital of Philadelphia; Nottingham Trent University; Conquer Cancer Foundation","keywords":"Myeloid leukemia; Medicine; Immune checkpoint; Blockade; Immunotherapy; Oncology; CD8; Immune system; Leukemia; Effector; Internal medicine; Immunology; Cancer research; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00223833,0.0001353062,0.0005323471,0.0002093538,0.00008896102,0.00001505181,0.000077029,0.0001194366,0.0001477662],"category_scores_gemma":[0.0005935045,0.0001082271,0.0002440807,0.0001950432,0.0002104872,0.0001378923,0.00006752384,0.0008748621,0.000001552821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003325676,"about_ca_system_score_gemma":0.0003407809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003804641,"about_ca_topic_score_gemma":0.000003674902,"domain_scores_codex":[0.9973664,0.0003364752,0.001525149,0.0001778271,0.0004505819,0.0001435318],"domain_scores_gemma":[0.9983861,0.0003523864,0.0009201987,0.0001436789,0.00005792311,0.0001397475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01617323,0.0002865636,0.5885846,0.00003773939,0.0007819501,0.0002700385,0.0004581181,0.0002806698,0.3796631,0.00001122083,0.001184505,0.01226826],"study_design_scores_gemma":[0.008073449,0.001783199,0.9798788,0.0000960967,0.0002237378,0.0004214025,0.0001986557,0.00021076,0.006319815,0.0004050956,0.002289909,0.0000991224],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920165,0.001493478,0.00002878473,0.005540783,0.000645153,0.0002287865,0.000009932838,0.000008260593,0.00002831876],"genre_scores_gemma":[0.9958116,0.0009201238,0.0009204864,0.001765558,0.0001563262,0.000009977613,0.00002185498,0.00001592216,0.0003781267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3912942,"threshold_uncertainty_score":0.4413372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03017100444525617,"score_gpt":0.3197234006004307,"score_spread":0.2895523961551745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}