{"id":"W4295459377","doi":"10.1016/j.trecan.2022.08.002","title":"TAZ/YAP fusion proteins: mechanistic insights and therapeutic opportunities","year":2022,"lang":"en","type":"review","venue":"Trends in cancer","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"National Health and Medical Research Council; National Cancer Institute; National Institutes of Health; Health Services Research and Development; Terry Fox Research Institute; Biomedical Laboratory Research and Development, VA Office of Research and Development; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Epigenetics; Fusion protein; Biology; Transcriptome; Hippo signaling pathway; Transcription factor; Computational biology; Genetics; Cell biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001000659,0.001242917,0.001612835,0.001575513,0.0002541799,0.00156355,0.001254894,0.001607193,0.002834648],"category_scores_gemma":[0.0009247829,0.0003265961,0.0005982738,0.001692129,0.0007002181,0.001592873,0.0007800492,0.003691981,0.00181019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001001441,"about_ca_system_score_gemma":0.001206554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009375915,"about_ca_topic_score_gemma":0.002461602,"domain_scores_codex":[0.9998099,0.00002568826,0.00002066103,0.00003553282,0.00007593431,0.00003234436],"domain_scores_gemma":[0.9996773,0.0001304698,0.0000364976,0.00001036116,0.00009315811,0.000052197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002118949,0.0001119423,0.0001919131,0.008304556,0.0001015232,0.0003032989,0.00004096191,0.0006781682,0.003529907,0.006303437,0.07655532,0.9036671],"study_design_scores_gemma":[0.00005724564,0.00009876004,0.0004878733,0.001319065,0.0001320646,0.0008853764,0.00003481899,0.0001630144,0.0008517895,0.002136768,0.9938108,0.00002235271],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001034116,0.9983369,0.0001859723,0.0005170717,0.000271658,0.000003665539,0.00002430238,0.00001099232,0.0005459953],"genre_scores_gemma":[0.0006374758,0.9979135,0.0002427219,0.0003561076,0.0002194535,0.000008023848,0.00004821757,0.000002331266,0.0005721675],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002834648,"threshold_uncertainty_score":0.009482861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1666160550811867,"score_gpt":0.368604095597057,"score_spread":0.2019880405158703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}