{"id":"W429551751","doi":"10.1200/jco.2006.24.18_suppl.3016","title":"Final clinical and pharmacokinetic (PK) results from a phase 1 study of the novel N-cadherin (N-cad) antagonist, Exherin (ADH-1), in patients with refractory solid tumors stratified according to N-cad expression","year":2006,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Medicine; Pharmacokinetics; Internal medicine; Refractory (planetary science); Dysgeusia; Cohort; Pharmacodynamics; Gastroenterology; Adverse effect; Urology; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00186385,0.001583211,0.001968303,0.0002906645,0.0004627771,0.0007501742,0.000416567,0.0009203469,0.002151882],"category_scores_gemma":[0.001648076,0.0005171349,0.001009465,0.0002665218,0.0008190976,0.0006707538,0.0003041365,0.002191918,0.0005260838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000733141,"about_ca_system_score_gemma":0.0007141284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000451006,"about_ca_topic_score_gemma":0.000687306,"domain_scores_codex":[0.9993734,0.0003312815,0.00003586746,0.0001097804,0.00006045975,0.00008928608],"domain_scores_gemma":[0.9989471,0.0002708648,0.000234775,0.0001128973,0.00008494818,0.000349468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5813253,0.06328029,0.03963337,0.0007266121,0.002675663,0.000849744,0.0008373442,0.006591243,0.1950507,0.000213651,0.0053615,0.1034546],"study_design_scores_gemma":[0.164223,0.7143208,0.09329235,0.00003182807,0.001350949,0.001149097,0.0001101005,0.002507205,0.0187484,0.0002292952,0.003949855,0.00008714469],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960837,0.0005958268,0.000754684,0.0001155731,0.00002286973,0.0008651578,0.0009636505,0.00005478217,0.0005437176],"genre_scores_gemma":[0.9937052,0.0004530888,0.001256894,0.0003144587,0.00005315284,0.0008104914,0.002375623,0.00002747995,0.001003553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002151882,"threshold_uncertainty_score":0.009857118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06641904893265617,"score_gpt":0.4235525304135426,"score_spread":0.3571334814808864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}