{"id":"W4295658348","doi":"10.1002/path.6011","title":"Periostin‐ and podoplanin‐positive cancer‐associated fibroblast subtypes cooperate to shape the inflamed tumor microenvironment in aggressive pancreatic adenocarcinoma","year":2022,"lang":"en","type":"article","venue":"The Journal of Pathology","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Société Nationale Française de Gastro-Entérologie; Fondation pour la Recherche Médicale; Cancer Research UK; CNIB","keywords":"Periostin; Podoplanin; Stromal cell; Cancer-Associated Fibroblasts; Immunostaining; Tumor microenvironment; Cancer research; Biology; Pancreatic cancer; Immune system; Pathology; Cancer; Tumor progression; Immunohistochemistry; Medicine; Immunology; Cell biology; Extracellular matrix","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002227975,0.0001692927,0.0001882637,0.0005771528,0.000211741,0.0003667012,0.00006872741,0.0001382347,0.0004707428],"category_scores_gemma":[0.000230902,0.0001381682,0.0002186103,0.0003326601,0.0001521232,0.0001611438,0.0001870636,0.0002504096,0.0001319515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001537214,"about_ca_system_score_gemma":0.0001489741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005196517,"about_ca_topic_score_gemma":0.0008844883,"domain_scores_codex":[0.9998525,0.00002348087,0.00001621886,0.00003563754,0.00003894667,0.0000330855],"domain_scores_gemma":[0.9998274,0.00002763963,0.00006404327,0.00002504968,0.0000198768,0.00003595076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003707831,0.00002687317,0.06068652,0.00004125179,0.00001991039,0.0002970672,0.0001157728,0.0001770753,0.9348529,0.000055433,0.00003825944,0.003318068],"study_design_scores_gemma":[0.00002922435,0.0003252003,0.7472885,0.00001081755,0.00008474963,0.004944483,0.0004947475,0.003602215,0.2409695,0.0002513943,0.001980219,0.00001892499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989737,0.0001968609,0.0005255615,0.000008598121,0.000001371707,0.000005886897,0.0001052982,0.00001489536,0.0001678166],"genre_scores_gemma":[0.9986885,0.0001244079,0.0007734144,0.00000914061,0.00000216009,0.000009405328,0.0001992334,0.000004843268,0.0001889413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005771528,"threshold_uncertainty_score":0.001574814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00985509176648698,"score_gpt":0.241121450656193,"score_spread":0.231266358889706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}