{"id":"W4295681858","doi":"10.3389/fncel.2022.953991","title":"Irisin stimulates protective signaling pathways in rat hippocampal neurons","year":2022,"lang":"en","type":"article","venue":"Frontiers in Cellular Neuroscience","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Institute for Translational Neuroscience; Instituto Serrapilheira; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Harvard University; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Alzheimer's Society; Weston Brain Institute; Alzheimer's Association","keywords":"FNDC5; Neuroprotection; Hippocampal formation; Neurotrophic factors; Neuroscience; MAPK/ERK pathway; Signal transduction; Brain-derived neurotrophic factor; Stimulation; Cell biology; Endocrinology; Biology; Internal medicine; Chemistry; Medicine; Fibronectin; Receptor; Extracellular matrix","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008373604,0.0003541959,0.0003125333,0.0002564843,0.0001777043,0.000205724,0.0001013078,0.0001834147,0.001594563],"category_scores_gemma":[0.00006349821,0.00009103423,0.0003209799,0.0002313776,0.0001842376,0.0001722157,0.0001789764,0.0006325503,0.000297982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002474911,"about_ca_system_score_gemma":0.0002179838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009432004,"about_ca_topic_score_gemma":0.002472803,"domain_scores_codex":[0.9999439,0.000004792539,0.000005453166,0.00001429003,0.00001043446,0.00002110397],"domain_scores_gemma":[0.9999595,0.000005803655,0.000009557401,0.000004699177,0.000004485872,0.00001593954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00103794,0.0001171102,0.0001924116,0.000117947,0.00001304945,0.0001124272,0.00003615571,0.00005020327,0.9952316,0.00005501853,0.0001021279,0.00293402],"study_design_scores_gemma":[0.00008859522,0.001476213,0.01108595,0.00002477194,0.00005232575,0.000213703,0.0001200968,0.0003893471,0.9846597,0.0001315418,0.00174982,0.000007955568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994027,0.002013791,0.0007909348,0.0001639491,0.00005950642,0.0000250462,0.0006753699,0.00008101344,0.002163449],"genre_scores_gemma":[0.9906411,0.002662917,0.00183402,0.0001363868,0.00002619018,0.00005941927,0.001097312,0.00001971323,0.003522947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001594563,"threshold_uncertainty_score":0.005334377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0254120531713268,"score_gpt":0.2485534069675119,"score_spread":0.223141353796185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}