{"id":"W4295690767","doi":"10.1002/hep.32781","title":"c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis","year":2022,"lang":"en","type":"article","venue":"Hepatology","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Medical Research Council Canada; Cancer Research UK; Newton Fund","keywords":"DNA damage; Cancer research; Doxorubicin; DNA repair; Biology; Cancer; Programmed cell death; Hepatocellular carcinoma; Transcription factor; Cell growth; Chemotherapy; Apoptosis; DNA; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001550706,0.0002707967,0.0002793552,0.0001022134,0.0008175338,0.00003225297,0.0006802897,0.0001638103,0.0001514663],"category_scores_gemma":[0.0003181468,0.0002445325,0.0001889833,0.000217665,0.0001767361,0.000003945544,0.0008326714,0.0003160756,0.00003086135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007055786,"about_ca_system_score_gemma":0.0002379688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007897231,"about_ca_topic_score_gemma":0.00005184555,"domain_scores_codex":[0.9966682,0.001362231,0.0004084568,0.0006672595,0.0003113606,0.0005824753],"domain_scores_gemma":[0.998526,0.0002305208,0.000208311,0.0008545237,0.00008361407,0.00009700222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000792878,0.00006362971,0.04116711,0.00001069185,0.00008117268,0.0001338335,0.0002307594,0.0006098168,0.9550472,0.0002169024,0.001332535,0.0003134797],"study_design_scores_gemma":[0.0006581469,0.000559556,0.002291095,0.00000672477,0.0000590233,0.000530664,0.0006039966,0.001403808,0.9609861,0.0002366433,0.03226137,0.000402836],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962477,0.001272217,0.0002052622,0.001205058,0.0004058757,0.0003039588,0.00005633721,0.00009017465,0.0002134297],"genre_scores_gemma":[0.9970446,0.00002670064,0.000250116,0.001560062,0.0002092415,0.0002034902,0.00009434386,0.00008808349,0.0005233141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03887602,"threshold_uncertainty_score":0.9971745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01674143642181023,"score_gpt":0.2311916508436224,"score_spread":0.2144502144218122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}