{"id":"W4295690767","doi":"10.1002/hep.32781","title":"c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis","year":2022,"lang":"en","type":"article","venue":"Hepatology","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Medical Research Council Canada; Cancer Research UK; Newton Fund","keywords":"DNA damage; Cancer research; Doxorubicin; DNA repair; Biology; Cancer; Programmed cell death; Hepatocellular carcinoma; Transcription factor; Cell growth; Chemotherapy; Apoptosis; DNA; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009508811,0.0004421021,0.0002045668,0.0001919217,0.0002510221,0.0002647874,0.0001999538,0.0002540595,0.002513113],"category_scores_gemma":[0.00005884722,0.0001109595,0.0002476245,0.0001363813,0.0003198451,0.0002420805,0.0002017844,0.0005797374,0.0007706489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004784772,"about_ca_system_score_gemma":0.0002673862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004660384,"about_ca_topic_score_gemma":0.0007235825,"domain_scores_codex":[0.9999037,0.00001018151,0.00000564531,0.00002698173,0.00001632659,0.00003725074],"domain_scores_gemma":[0.9999287,0.000004285762,0.00002400171,0.000005308724,0.000007984812,0.00002975082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005583282,0.0000503673,0.0003088686,0.00007404968,0.000004537399,0.00006202981,0.000009731498,0.00007783547,0.9973404,0.000114666,0.0001250982,0.001274172],"study_design_scores_gemma":[0.0001108314,0.0004598477,0.01431327,0.00001936289,0.00002780916,0.000442465,0.00006391438,0.001110184,0.9787986,0.0001393237,0.004503192,0.00001124672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875304,0.005306369,0.002290111,0.0002957068,0.0000713566,0.00004941106,0.001036893,0.0002192988,0.003200582],"genre_scores_gemma":[0.9946048,0.001158058,0.001128062,0.00008144572,0.00001925266,0.00004733691,0.000588697,0.00002900344,0.002343439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002513113,"threshold_uncertainty_score":0.008407176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01674143642181023,"score_gpt":0.2311916508436224,"score_spread":0.2144502144218122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}