{"id":"W4295706100","doi":"10.1126/sciadv.abp9435","title":"Exosome-mediated delivery of Cas9 ribonucleoprotein complexes for tissue-specific gene therapy of liver diseases","year":2022,"lang":"en","type":"article","venue":"Science Advances","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":276,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Exosome; Ribonucleoprotein; Gene delivery; Genome editing; Cas9; Biology; Genetic enhancement; CRISPR; Electroporation; Cell biology; Microvesicles; Cancer research; Gene; RNA; microRNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000176948,0.0001082857,0.0001647025,0.00009269358,0.000204724,0.00001040687,0.0005200043,0.00002160422,0.00007241135],"category_scores_gemma":[0.00003486651,0.00009857037,0.00007508793,0.0002799394,0.0008093183,0.00002425767,0.0001661077,0.00003614725,0.000001758667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001555986,"about_ca_system_score_gemma":0.0001296713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002937989,"about_ca_topic_score_gemma":0.00001318238,"domain_scores_codex":[0.9988905,0.00003010333,0.0002197451,0.00035175,0.000284964,0.0002229162],"domain_scores_gemma":[0.9992521,0.00002759231,0.0001661262,0.0002838158,0.0002155502,0.00005476342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002177756,0.00009435004,0.0007500945,0.00001305385,0.000009879448,0.000001311646,0.00007475873,0.0002850175,0.9769436,0.00004601472,0.0002009978,0.02136315],"study_design_scores_gemma":[0.000340389,0.0009955113,0.003135486,0.00000651997,0.000003546333,0.00000363567,0.0002742066,0.00003507669,0.9622862,0.0001638355,0.03262933,0.0001263027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758387,0.0227811,0.0004840969,0.00002618279,0.0001588509,0.0002946912,0.0003681594,0.000006435642,0.00004184338],"genre_scores_gemma":[0.9961991,0.002353446,0.001057881,0.0000709552,0.00005642364,0.00007195687,0.00008080181,0.000008717424,0.0001007342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03242833,"threshold_uncertainty_score":0.4019583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01956286116270214,"score_gpt":0.2723259707653906,"score_spread":0.2527631096026885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}