{"id":"W4295706100","doi":"10.1126/sciadv.abp9435","title":"Exosome-mediated delivery of Cas9 ribonucleoprotein complexes for tissue-specific gene therapy of liver diseases","year":2022,"lang":"en","type":"article","venue":"Science Advances","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":276,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Exosome; Ribonucleoprotein; Gene delivery; Genome editing; Cas9; Biology; Genetic enhancement; CRISPR; Electroporation; Cell biology; Microvesicles; Cancer research; Gene; RNA; microRNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002611124,0.0003608428,0.000272855,0.0002252258,0.0001739366,0.0003528986,0.0002068238,0.0003452326,0.0008595703],"category_scores_gemma":[0.0001631923,0.000131074,0.0002803783,0.0001322351,0.0002305392,0.0003236567,0.0003373869,0.0005119362,0.0003164541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003170082,"about_ca_system_score_gemma":0.0002910494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003101412,"about_ca_topic_score_gemma":0.0003780811,"domain_scores_codex":[0.9997923,0.00004200594,0.0000262235,0.00005228232,0.0000654969,0.00002167434],"domain_scores_gemma":[0.9999439,0.00001013285,0.00001809534,0.000008161282,0.00001061947,0.000009116541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004246182,0.00001681278,0.00008148779,0.00008413256,0.00001028251,0.000068855,0.00001773864,0.0001512266,0.9927469,0.0005493462,0.0001462786,0.006084516],"study_design_scores_gemma":[0.00001016217,0.00009614135,0.0003463884,0.000006109027,0.00001811872,0.0002465706,0.000006568152,0.001661785,0.9905625,0.00009452894,0.006944248,0.000006895065],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6520201,0.01944838,0.3162387,0.0009001378,0.0005309144,0.0004131043,0.0007652045,0.001203731,0.008479681],"genre_scores_gemma":[0.9458121,0.006504576,0.0405601,0.0001835035,0.00004451449,0.0001175867,0.0006288634,0.00009372226,0.00605494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008595703,"threshold_uncertainty_score":0.002875507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01956286116270214,"score_gpt":0.2723259707653906,"score_spread":0.2527631096026885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}