{"id":"W4295745238","doi":"10.3389/fonc.2022.973402","title":"Comprehensive immune profiling of patients with advanced urothelial or renal cell carcinoma receiving immune checkpoint blockade","year":2022,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency; Terry Fox Research Institute; Surrey Place Centre","funders":"","keywords":"Immune system; CXCR4; Mass cytometry; Nivolumab; Immune checkpoint; Chemokine; Immunology; Cancer research; Medicine; Chemokine receptor; Flow cytometry; Immunotherapy; Pembrolizumab; CCR4; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001491913,0.0001351009,0.0003514408,0.0004892423,0.0001984397,0.0003308427,0.0001103351,0.0002232418,0.0005243114],"category_scores_gemma":[0.0004214877,0.0000821975,0.0001785842,0.0004022559,0.00008965232,0.0001375696,0.0001601704,0.0002161847,0.0001288265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001253007,"about_ca_system_score_gemma":0.0001061277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005180871,"about_ca_topic_score_gemma":0.0006301185,"domain_scores_codex":[0.9998484,0.00002658554,0.00001622574,0.00004865543,0.00002443352,0.00003573762],"domain_scores_gemma":[0.9998099,0.0000494785,0.00005149132,0.00001623417,0.0000300468,0.00004283061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001454353,0.00009454191,0.9210181,0.00006527203,0.0000719357,0.001072639,0.0002631765,0.0002888541,0.04989561,0.0000424082,0.0003584707,0.02537468],"study_design_scores_gemma":[0.00001337135,0.0006329625,0.9929133,0.000007065228,0.00005136909,0.001669033,0.0001669933,0.0004364372,0.003148576,0.00003234153,0.0009230877,0.000005374762],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989765,0.0003427223,0.0001641069,0.00002268751,0.000002864645,0.00001118941,0.0002115535,0.000007484894,0.0002610564],"genre_scores_gemma":[0.9990087,0.0001188323,0.0002451342,0.00004438484,0.000007430011,0.00001295413,0.0003778797,0.000002531483,0.0001821572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005243114,"threshold_uncertainty_score":0.001753986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01191678271423394,"score_gpt":0.2591145183900955,"score_spread":0.2471977356758615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}