{"id":"W4295754160","doi":"10.1002/prp2.1003","title":"The signaling and selectivity of α‐adrenoceptor agonists for the human <scp>α2A</scp>, <scp>α2B</scp> and <scp>α2C</scp>‐adrenoceptors and comparison with human α1 and β‐adrenoceptors","year":2022,"lang":"en","type":"article","venue":"Pharmacology Research & Perspectives","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Graduate Education; Medical Research Council; Medical Research Council Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Adrenergic receptor; Agonist; Receptor; Pharmacology; Medicine; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.003296856,0.0005297637,0.0006516481,0.0002620377,0.00520147,0.0002797738,0.0006056249,0.0002369235,0.00004923145],"category_scores_gemma":[0.0007195737,0.0003959282,0.0001323899,0.0004359708,0.002613447,0.00004464497,0.001009393,0.001164042,6.42461e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001080374,"about_ca_system_score_gemma":0.0002220126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000182365,"about_ca_topic_score_gemma":0.0001248034,"domain_scores_codex":[0.9951656,0.001167754,0.0004963603,0.001307445,0.0006601787,0.001202663],"domain_scores_gemma":[0.9950104,0.003346025,0.0003562038,0.0003607064,0.0005697609,0.0003569065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008104819,0.000273108,0.01279748,0.0001079626,0.0008158878,0.000004938163,0.01116832,0.00009086855,0.9630657,0.001005603,0.009874849,0.0007142094],"study_design_scores_gemma":[0.003434025,0.004728311,0.00733379,0.0000292551,0.0002988729,0.00009766472,0.09505651,0.0005990287,0.8550313,0.001232916,0.03197853,0.0001797972],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9727143,0.02453095,0.0002901789,0.0002317168,0.0001679574,0.00160155,0.00009709151,0.00003730471,0.000328946],"genre_scores_gemma":[0.9952181,0.002026455,0.000259496,0.00007080343,0.0004894903,0.0005537589,0.0000464243,0.00009896091,0.001236515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1080344,"threshold_uncertainty_score":0.9998493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0356700284963453,"score_gpt":0.3604418743473887,"score_spread":0.3247718458510434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}