{"id":"W4295763170","doi":"10.1038/s41586-022-05194-y","title":"Control of cell state transitions","year":2022,"lang":"en","type":"article","venue":"Nature","topic":"Cell Image Analysis Techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Medical Research Council; National Cancer Institute; Cancer Research UK; Science Foundation Ireland; National Institutes of Health; Children's Health Foundation; Brain Tumour Charity","keywords":"Workflow; Signalling; Flexibility (engineering); Systems biology; Computer science; Computational biology; Cell fate determination; Cell; Scalability; Biology; Cell biology; Genetics; Mathematics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002279053,0.0002443213,0.0002412457,0.0003401387,0.0003556916,0.00144852,0.0005190977,0.0002667809,0.004097926],"category_scores_gemma":[0.0006065603,0.000201979,0.0002216054,0.0002093804,0.0004706665,0.0006777928,0.000576487,0.000651177,0.0006962094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006220437,"about_ca_system_score_gemma":0.0001965841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000517214,"about_ca_topic_score_gemma":0.0009962081,"domain_scores_codex":[0.9998216,0.00002191174,0.000007714259,0.00005736604,0.00004801988,0.00004341417],"domain_scores_gemma":[0.9997612,0.00007083203,0.00004258748,0.00004568548,0.00002564446,0.00005413506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000170485,0.00004977424,0.0004491339,0.00004299287,0.00001005179,0.00006974838,0.0001185632,0.0009113929,0.9649699,0.0177719,0.0008081484,0.01462795],"study_design_scores_gemma":[0.00003930188,0.0001134704,0.007426744,0.00001680506,0.0000186377,0.0001474952,0.000117527,0.02877685,0.9378853,0.01263205,0.01279506,0.00003065397],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8956973,0.003574296,0.0656109,0.001223907,0.0007346856,0.00008003504,0.0007567495,0.001257998,0.03106404],"genre_scores_gemma":[0.9930487,0.0004740253,0.001864148,0.00009143751,0.00002858927,0.00003563228,0.000115472,0.00008668662,0.004255355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004097926,"threshold_uncertainty_score":0.01370895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001781115657336212,"score_gpt":0.2251860137023511,"score_spread":0.2234048980450149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}